Results 151 to 160 of about 192,874 (223)
Impact of COVID‐19 on Subsequent Lung Function in Childhood: A Systematized Review
ABSTRACT Background and Aims The SARS‐CoV‐2 infection can lead to transiently altered lung function in adults, but data is less clear in children. We aimed to summarize the available evidence about respiratory outcomes after COVID‐19 in childhood. Methods We conducted a literature search on post‐COVID‐19 lung function tests (LFT) on the Medline and ...
Benedetta De Santis +3 more
wiley +1 more source
ABSTRACT By preserving molecular information inherited from the source cell, extracellular vesicles (EVs) can serve as biomarkers for tissue health or disease, paving the way for liquid biopsy applications. The enrichment of tissue‐specific EVs (TS‐EVs) from human biofluids can be challenging due to technical and methodological limitations.
Biancamaria Pierri +11 more
wiley +1 more source
Mapping the Severity of Phenylalanine Hydroxylase Deficiency
ABSTRACT Since the 1960s, phenylalanine hydroxylase (PAH) deficiency can be detected via newborn screening, allowing early start of treatment to prevent severe intellectual disability. Precise determination of PAH deficiency severity continues to be hampered by several factors.
S. Haitjema +5 more
wiley +1 more source
ABSTRACT Almost all patients with mucopolysaccharidosis (MPS) develop respiratory dysfunction of varying severity during disease progression. While respiratory disease in MPS has traditionally been attributed to upper airway obstruction caused by glycosaminoglycan (GAG) accumulation in the trachea and bronchi, involvement of the intrapulmonary ...
Martin Donnelley +14 more
wiley +1 more source
The Role of Urea Cycle Functional Studies in Preclinical Research
ABSTRACT Inborn errors of metabolism affecting the urea cycle are rare severe conditions caused by impaired nitrogen detoxification, leading to hyperammonemia and neurological morbidity across a broad clinical spectrum. Current biochemical diagnostics largely rely on quantification of metabolites. While indispensable for diagnosis and acute management,
Nathan Breuillard +5 more
wiley +1 more source
ABSTRACT Purpose To develop and evaluate Crohn‐BOOST, an open‐source tool enabling semi‐automatic segmentation of intestinal lesions and creeping fat on magnetic resonance enterography (MR Enterography), and to assess whether quantitative metrics derived from these segmentations relate to radiological disease activity scored with simplified MaRIA ...
Antoine Kneib +5 more
wiley +1 more source
ABSTRACT Purpose To improve accuracy and repeatability of myocardial 23Na quantification in cardiac MRI at 7 T by combining retrospective respiratory and cardiac motion correction with a novel anatomy‐based B1 bias field correction. Methods In this study, a dual‐nuclear interleaved 23Na/1H MRI sequence at 7 T was applied.
Laurent Ruck +10 more
wiley +1 more source
Randomized controlled trial of traxi panniculus retractor use during non‐emergent cesarean delivery
Abstract Objective The objective of our study is to determine whether the use of a self‐retaining panniculus retraction device (traxi) in patients with obesity will improve operative time, pulmonary function, or patient and provider experience for non‐emergent cesarean delivery.
Tooba Anwer +10 more
wiley +1 more source

