Results 121 to 130 of about 933,719 (257)

Determinação do componente inflamatório das doenças das vias aéreas através do escarro induzido: utilização na prática clínica [PDF]

, 2007
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-graduação em Ciências MédicasIntrodução: Além de um importante instrumento de pesquisa, a celularidade do escarro induzido (EI) vem sendo ...
Moritz, Pablo
core  

Targeting Airway Remodeling in Severe Asthma: Is There a Window of Opportunity for Biologic Therapy Predicting Effects Using Causal Artificial Intelligence?

Allergy, EarlyView.
ABSTRACT Airway remodeling is increasingly recognized as a major determinant of asthma progression, fixed airflow limitation, and long‐term morbidity, particularly in severe disease. Although biologic therapies have transformed outcomes by reducing exacerbations and systemic corticosteroid exposure, their potential to modify structural airway ...
Sebastiano Gangemi, Sara Manti, Johann Christian Virchow, Giorgio Walter Canonica   +3 more
wiley   +1 more source

Silent zone detection in asthma and its relation to T2 inflammation

Egyptian Journal of Chest Disease and Tuberculosis
Objective Study objectives are to detect small airways disease in asthma and to study T2 inflammatory markers (eosinophil count, IgE, phenotyping) in association with small airways disease.
Hala Samaha, Dalia Elhassan, Afnan Tayeb
doaj   +1 more source

Fractional exhaled nitric oxide-measuring devices: technology update

Medical Devices: Evidence and Research, 2016
Mauro Maniscalco,1 Carolina Vitale,2 Alessandro Vatrella,2 Antonio Molino,3 Andrea Bianco,4 Gennaro Mazzarella4 1Unit of Respiratory Diseases, Hospital “S Maria della Pietà” of Casoria, Naples, 2Unit of Respiratory Medicine, Department
Maniscalco M, Vitale C, Vatrella A, Molino A, Bianco A, Mazzarella G   +5 more
doaj  

A Real‐World Controlled Multicentre Study Evaluating the Association Between Benralizumab Therapy and Major Outcomes in Severe Asthma

Clinical &Experimental Allergy, EarlyView.
Among patients with severe eosinophilic asthma, benralizumab was associated with greater improvements in asthma outcomes—such as improved asthma control, quality of life and remission rates—compared to biologic‐naïve patients. ABSTRACT Background Real‐world data on benralizumab in patients with severe eosinophilic asthma–while controlling for ...
Dennis Thomas, Vanessa M. McDonald, Gijo Thomas, Joy Lee, Li Ping Chung, Matthew Peters, Shakti D. Shukla, Yuto Hamada, Erin S. Harvey, Michael Fricker, Hayley See, Rejoy Sabin Thomas, Claude S. Farah, Andrew Gillman, Constance H. Katelaris, Gregory P. Katsoulotos, David Langton, Peter G. Middleton, Paul Reynolds, Janet Rimmer, Francis Thien, Stephen Vincent, John W. Upham, Peter G. Gibson   +23 more
wiley   +1 more source

Inflammatory Mediators Associated With Corticosteroid Responsiveness During Asthma Attacks

Clinical &Experimental Allergy, EarlyView.
ABSTRACT Higher baseline sputum/serum eotaxin‐3 and serum IL‐5 levels were associated with greater FEV1 improvement following OCS during asthma attacks. Corticosteroid‐induced inflammatory modulation differed across T2 phenotypes during asthma attacks.
Carlos Celis‐Preciado, Elsa Ben Hamou Kuijpers, Mohamed‐Ilias Kourid, Simon Leclerc, Martine Duval, Dominic O. Cliche, Félix‐Antoine Vézina, Pierre Larivée, Samuel Lemaire‐Paquette, Philippe Lachapelle, Martin Klein, Simon Couillard   +11 more
wiley   +1 more source

Evaluating Whole Fruit Feijoa Powder for Type 2 Diabetes Risk Prevention: A Randomised Controlled Trial

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Low energy diets (LEDs) are effective for body weight (BW) loss and improvement of type 2 diabetes (T2D) risk biomarkers. Emerging evidence suggests that whole fruit feijoa powder, rich in polyphenols and abscisic acid, may further support T2D prevention.
I. A. Mohamed, I. R. Sequeira‐Bisson, J. J. Lim, L. D. Plank, R. Murphy, S. D. Poppitt, J. L. Miles‐Chan   +6 more
wiley   +1 more source

Exhaled Nitric Oxide in Systemic Sclerosis Lung Disease

Canadian Respiratory Journal, 2017
Background. Exhaled nitric oxide (eNO) is a potential biomarker to distinguish systemic sclerosis (SSc) associated pulmonary arterial hypertension (PAH) and interstitial lung disease (ILD).
Natalie K. Kozij, John T. Granton, Philip E. Silkoff, John Thenganatt, Shobha Chakravorty, Sindhu R. Johnson   +5 more
doaj   +1 more source

A new era beckons in asthma: enhanced models of care, disease remission, artificial intelligence and consumer participation

Internal Medicine Journal, EarlyView.
Abstract The landscape of asthma management is undergoing significant transformation. This change is driven by several factors: deeper understanding of asthma pathophysiology, appreciation of the long‐term harm of oral corticosteroids, biological treatments that dramatically improve patient outcomes with asthma remission becoming a realistic goal, and ...
John Politis, Kerry Hancock, Jo A Douglass, Paul Leong, Philip Bardin   +4 more
wiley   +1 more source

Diagnosing primary ciliary dyskinesia in Australian adults: 10 years of testing

Internal Medicine Journal, EarlyView.
Abstract Primary ciliary dyskinesia (PCD) is a rare inherited disorder characterised by impaired ciliary function, leading to chronic upper and lower airway disease from early life. Limited awareness of the condition contributes to delayed diagnosis, with some individuals first diagnosed in adulthood following specialised testing. We describe 91 adults
P. J. Robinson
wiley   +1 more source