Results 41 to 50 of about 602,474 (294)

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Acute HIV Infection and ART Response: Insights into T Cell Subsets, Activation, Exhaustion, and Blood and GALT HIV Reservoir

Viruses
Investigating immunological and viral reservoir dynamics in blood and GALT during acute HIV phase advances understanding of HIV persistence. Dynamics of T cells and HIV reservoirs immediately after early ART require further investigation.
Soraia Santana de Moura, Diogo Gama Caetano, Monick Lindenmeyer Guimarães, Rayana Katylin Mendes da Silva, Natasha Cabral, Simone da Costa Cruz Silva, Marcelo Ribeiro-Alves, Sylvia L. M. Teixeira, Ingebourg Georg, Desirée Vieira Gomes dos Santos, Sandro Nazer, Rafael Teixeira Fraga, Brenda Hoagland, Larissa Villela, Beatriz Gilda Jegerhorn Grinsztejn, Valdiléa Gonçalves Veloso, Fernanda Heloise Côrtes, Sandra W. Cardoso   +17 more
doaj   +1 more source

Quantifying Burnout among Emergency Medicine Professionals

Journal of Emergencies, Trauma and Shock, 2017
Background: Burnout is a syndrome explained as serious emotional depletion with poor adaptation at work due to prolonged occupational stress. It has three principal components namely emotional exhaustion(EE), depersonalization(DP) and diminished feelings
William Wilson, Jeffrey Pradeep Raj, Girish Narayan, Murtuza Ghiya, Shakuntala Murty, Bobby Joseph   +5 more
doaj   +1 more source

Modulation of natural killer cell exhaustion in the lungs: the key components from lung microenvironment and lung tumor microenvironment

Frontiers in Immunology, 2023
Lung cancer is the leading cause of tumor-induced death worldwide and remains a primary global health concern. In homeostasis, due to its unique structure and physiological function, the lung microenvironment is in a state of immune tolerance and ...
Hongxia Zhang, Jian Wang, Jian Wang, Fengqi Li   +3 more
doaj   +1 more source

Recovery of endurance running capacity: effect of carbohydrate-protein mixtures [PDF]

, 2005
Including protein in a carbohydrate solution may accelerate both the rate of glycogen storage and the restoration of exercise capacity following prolonged activity. Two studies were undertaken with nine active men in study A and seven in study B.
Betts, James, Grey, Edwin, Griffin, Joe, Sheppard, Catrin, Stevenson, Emma, Williams, Clyde   +5 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Associations between Psychosocial Work Environment Factors with Work Engagement and Burnout in Nursing

Psichologija, 2019
The psychosocial work environment (i.e., job demands and resources) is a significant determinant of nurses’ health and motivation; yet, despite the close associations between specific work environment factors, various frameworks suggest different aspects
Arūnas Žiedelis
doaj   +1 more source

A Workplace Study: Follow-Up Research Report [PDF]

, 2007
In response to the Partnerships for Children and Families Project\u27s study of Canadian child welfare workers that unexpectedly found participants scoring high on a measure of emotional exhaustion (burnout), and at the same time, high on overall job ...
Frensch, Karen, Harvey, Cheryl, Mandell, Deena, Stalker, Carol A., Wright, Margriet   +4 more
core   +1 more source

Work-related psychological health and psychological type among lead elders within the Newfrontiers network of churches in the United Kingdom [PDF]

, 2012
Building on a series of recent studies concerned with assessing work-related psychological health and psychological type among various groups of church leaders, this study reports new data provided by 134 Lead Elders within the Newfrontiers network of ...
Bradburn N. M., Evers W., Francis L. J., Francis L. J., Francis L. J., Francis L. J., Francis L. J., Francis L. J., Golden J., Jung C. G., Kay W. K., Lemkau J. P., Leslie J. Francis, Mandy Robbins, Maslach C., Myers I. B., Reid J., Robbins M., Robbins M., Rutledge C. J. F., Rutledge C. J. F., Sean Gubb, Strümpfer D. J. W., Warner J.   +23 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source