Results 101 to 110 of about 8,161,835 (383)

Linear Pantographic Sheets: Existence and Uniqueness of Weak Solutions

open access: yesJournal of elasticity, 2017
The well-posedness of the boundary value problems for second gradient elasticity has been studied under the assumption of strong ellipticity of the dependence on the second placement gradients (see, e.g., Chambon and Moullet in Comput. Methods Appl. Mech.
V. Eremeyev   +3 more
semanticscholar   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

The Relativity of Existence [PDF]

open access: yes, 2012
Despite the success of modern physics in formulating mathematical theories that can predict the outcome of experiments, we have made remarkably little progress towards answering the most fundamental question of: why is there a universe at all, as opposed
Heinrich, Stuart
core  

On the Existence of Digital Objects

open access: yes, 2016
This thesis is a philosophical investigation of such digital objects as images, videos and facebook objects which pervade our everyday life online and constitute a digital milieu with which we live.
Yuk Hui
semanticscholar   +1 more source

Pre-Existence and Post-Existence of Thought [PDF]

open access: yesNature, 1885
To express any views on these subjects one might well have hesitated some years ago, as hereditary transmission, tolerated as a doctrine, chiefly with regard to the breeding of sheep and dogs, was held to be unphilosophical. Darwin has settled the matter in the domain of science, but perhaps without altogether disposing of prejudices. Mr.
openaire   +3 more sources

A Targeted Existence

open access: yes, 2016
Over the summer, I visited a friend from Gettysburg who was having a party. The party was fun for the first half, and I was having a good time, so I decided to stay the night instead of walk in the dark to the bus.
Lauro, Melissa J.
core  

Existence of an extinction wave in the Fisher equation with a shifting habitat

open access: yes, 2017
. This paper deals with the existence of traveling wave solutions of the Fisher equation with a shifting habitat representing a transition to a devastating environment.
Haijun Hu, X. Zou
semanticscholar   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

The Harmlessness of Existence

open access: yesEthical Theory and Moral Practice, 2017
Can existence benefit or harm a person? I argue that it cannot. In order for existence to harm a person it has to be the case that existence is worse for the person than never existing. This claim could only be true if it is understood as a claim about the actual, extrinsic value of existence for a person.
openaire   +4 more sources

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

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