Results 81 to 90 of about 8,396,811 (368)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

open access: yesFEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue   +6 more
wiley   +1 more source

OUTLOOK FUNDAMENTALS OF THE TERM “SPIRITUALITY” INTERPRETATION BY THE UKRAINIAN EDUCATORS (THE SECOND HALF OF THE XIX CENTURY)

open access: yesОсвітній дискурс, 2019
The article deals with the ideological principles of interpretation of the term “spirituality” by Ukrainian educators of the second half of the nineteenth century.
Olga Tsybulko
doaj   +1 more source

The Harmlessness of Existence

open access: yesEthical Theory and Moral Practice, 2017
Can existence benefit or harm a person? I argue that it cannot. In order for existence to harm a person it has to be the case that existence is worse for the person than never existing. This claim could only be true if it is understood as a claim about the actual, extrinsic value of existence for a person.
openaire   +3 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

open access: yesFEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo   +2 more
wiley   +1 more source

Analytic solutions for iterative functional differential equations

open access: yesElectronic Journal of Differential Equations, 2012
Because of its technical difficulties the existence of analytic solutions to the iterative differential equation $x'(z)=x(az+bx(z)+c x'(z))$ is a source of open problems.
Pingping Zhang
doaj  

On existence of canonical $G$-bases

open access: yes, 2017
We describe a general method for expanding a truncated G-iterative Hasse-Schmidt derivation, where G is an algebraic group.
Hoffmann, Daniel M.
core   +1 more source

Hematopoietic (stem) cells—The elixir of life?

open access: yesFEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo   +4 more
wiley   +1 more source

Existence and non-existence results for Kirchhoff-type problems with convolution nonlinearity

open access: yesAdvances in Nonlinear Analysis, 2018
This paper is concerned with the following Kirchhoff-type problem with convolution nonlinearity: - ( a + b ∫ ℝ 3 | ∇ u | 2 d x ) Δ u + V ( x ) u = ( I α * F ( u ) ) f ( u ) , x ∈ ℝ 3 , u ∈ H 1 ( ℝ 3 ) , -\bigg{(}a+b\int_{\mathbb{R}^{3}}\lvert\nabla u|^{2}
Sitong Chen, Binlin Zhang, Xianhua Tang
semanticscholar   +1 more source

Existence Criterion of Genuine Tripartite Entanglement

open access: yes, 2006
In this paper, an intuitive mathematical formulation is provided to generalize the residual entanglement for tripartite systems of qubits [Phys. Rev. A 61, 052306 (2000)] to the tripartite systems in higher dimension.
A. Peres   +5 more
core   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

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