Results 91 to 100 of about 500,030 (282)

On systems of continuity equations with nonlinear diffusion and nonlocal drifts

open access: yes, 2015
This paper is devoted to existence and uniqueness results for classes of nonlinear diffusion equations (or systems) which may be viewed as regular perturbations of Wasserstein gradient flows. First, in the case.
Carlier, Guillaume, Laborde, Maxime
core  

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

On well-posedness for the Benjamin-Ono equation

open access: yes, 2005
We prove existence of solutions for the Benjamin-Ono equation with data in $H^s(\R)$, $s>0$. Thanks to conservation laws, this yields global solutions for $H^\frac 1 2(\R)$ data, which is the natural ``finite energy'' class.
Burq, N., Planchon, F.
core   +1 more source

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Optimal pair of fixed points: existence, uniqueness and approximation

open access: yesFixed Point Theory and Algorithms for Sciences and Engineering
In this paper, we introduce a novel class of mappings, referred to as noncyclic generalized θ-contractions. By employing the geometric concept of W U C $WUC$ property in metric spaces, we establish new existence and convergence theorems for the fixed ...
A. Safari-Hafshejani, M. Gabeleh
doaj   +1 more source

Existence and uniqueness for a Ginzburg-Landau system for superconductivity

open access: yesElectronic Journal of Differential Equations, 2020
We prove the existence of a unique solution for a time-dependent Ginzburg-Landau model in superconductivity under the Coulomb gauge. Also we prove the uniform-in-$\epsilon$ well-posedness of the solution, where $\epsilon$ is the coefficient of the ...
Jishan Fan, Yong Zhou
doaj  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Existence of solutions to fractional order ordinary and delay differential equations and applications

open access: yesElectronic Journal of Differential Equations, 2011
In this article, we discuss the existence and uniqueness of solution to fractional order ordinary and delay differential equations. We apply our results on the single species model of Lotka Volterra type.
Syed Abbas
doaj  

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