Results 101 to 110 of about 504,362 (312)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Existence of solutions to fractional order ordinary and delay differential equations and applications

Electronic Journal of Differential Equations, 2011
In this article, we discuss the existence and uniqueness of solution to fractional order ordinary and delay differential equations. We apply our results on the single species model of Lotka Volterra type.
Syed Abbas
doaj  

Existence and uniqueness for a Ginzburg-Landau system for superconductivity

Electronic Journal of Differential Equations, 2020
We prove the existence of a unique solution for a time-dependent Ginzburg-Landau model in superconductivity under the Coulomb gauge. Also we prove the uniform-in-$\epsilon$ well-posedness of the solution, where $\epsilon$ is the coefficient of the ...
Jishan Fan, Yong Zhou
doaj  

Existence and stability of a unique almost periodic solution for a prey-predator system with impulsive effects and multiple delays [PDF]

, 2016
Baodan Tian, Shouming Zhong, Ning Chen
openalex   +1 more source

On the Sparsity Bound for the Existence of a Unique Solution in\n Compressive Sensing by the Gershgorin Theorem [PDF]

, 2021
Ljubiša Stanković
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

Existence and Uniqueness of Second-Order Impulsive Delay Differential Systems

Axioms
In this paper, we study the existence and uniqueness of second-order impulsive delay differential systems. Firstly, we define cosine-type and sine-type delay matrix functions, which are used to derive the solutions of the impulsive delay differential ...
Yingxia Zhou, Mengmeng Li
doaj   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Multi-valued backward stochastic differential equations with regime switching

Advances in Difference Equations, 2019
The paper considers a class of multi-valued backward stochastic differential equations with subdifferential of a lower semi-continuous convex function with regime switching, whose generator is a continuous-time Markov chain with a finite state space ...
Ruijuan Deng, Yong Ren
doaj   +1 more source