Results 81 to 90 of about 504,503 (314)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

On the existence of a solution of a class of non-stationary free boundary problems

open access: yes, 2018
We consider a class of parabolic free boundary problems with heterogeneous coefficients including, from a physical point of view, the evolutionary dam problem. We establish existence of a solution for this problem.
Abdeslem Lyaghfouri   +5 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Existence of local and global solution for a spatio-temporal predator-prey model

open access: yesUniversitas Scientiarum, 2019
In this paper we prove the existence and uniqueness of weak solutions for a kind of Lotka–Volterra system, by using successive linearization techniques. This approach has the advantage to treat two equations separately in each iteration step.
Ricardo Cano Macias, Jorge Mauricio Ruiz V
doaj   +1 more source

The existence of a global fundamental solution for homogeneous Hormander operators via a global lifting method

open access: yes, 2017
We prove the existence of a global fundamental solution Gamma(x; y) (with pole x) for any Hormander operator L = sum_{i=1}^m X_i^2 on R^n which is delta_lambda-homogeneous of degree 2.
Biagi, S.   +3 more
core   +1 more source

The Existence of a Generalized Solution of an m-Point Nonlocal Boundary Value Problem [PDF]

open access: yes, 2017
An m-point nonlocal boundary value problem is posed for quasi- linear differential equations of first order on the plane. Nonlocal boundary value problems are investigated using the algorithm of reducing nonlocal boundary value problems to a sequence of ...
David Devadze, Devadze, David
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Existence of a solution to the principal's problem

open access: yes, 1987
This article deals with the existence of a solution to the Principal Agent Problem. Here we develops some basic results with the aid of Berge's Maximum Theorem.
Carlos Ivan Simonsen Leal   +1 more
core   +1 more source

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