Results 81 to 90 of about 251,066 (317)
Molecular bases of circadian magnesium rhythms across eukaryotes
FEBS Letters, EarlyView.Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley +1 more source
Asymptotic behavior of a Balakrishnan-Taylor suspension bridge
Electronic Research ArchiveIn this manuscript, we examine a nonlinear Cauchy problem aimed at describing the deformation of the deck of either a footbridge or a suspension bridge in a rectangular domain $ \Omega = (0, \pi)\times (-d, d) $, with $ d < < \pi $, incorporating ...
Zayd Hajjej
doaj +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Existence, uniqueness and constructive results for delay differential equations
Electronic Journal of Differential Equations, 2005 Here, we investigate boundary-value problems (BVPs) for systems of second-order, ordinary, delay-differential equations. We introduce some differential inequalities such that all solutions (and their derivatives) to a certain family of BVPs satisfy some ...
Paul W. Eloe +2 more
doaj
Global Regular Axially Symmetric Solutions to the Navier–Stokes Equations: Part 2
MathematicsThe axially symmetric solutions to the Navier–Stokes equations are considered in a bounded cylinder Ω⊂R3 with the axis of symmetry. S1 is the boundary of the cylinder parallel to the axis of symmetry, and S2 is perpendicular to it.
Wojciech M. Zajączkowski
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Existence of solutions of some boundary value problems with stochastic volatility. [PDF]
Heliyon, 2020 Osu BO, Eze EO, Obasi UE, Ukomah HI.
europepmc +1 more source