Results 61 to 70 of about 251,787 (265)
Freedom and Commitment: Does Kant Hold a Subjectivist Theory of Freedom?
FilozofiaAccording to a Subjectivist theory of X, reference to belief in the existence of X enters essentially into a full account of what the existence of X consists in.
Galen Strawson
doaj +1 more source
To Inform about the Non-Existent Objects in Mulla Sadra and Williamson’s View and Answer to their Challenges in the Framework of Allameh Tabatabaii’s Theory [PDF]
حکمت معاصر, 2013 This paper tries to answer to these questions: what is Mulla Sadra and Williamson’s solution to state the problem of non-existent objects and what are their similarities and differences and, moreover, challenges of these views.
Reza Akbarian, Siavash Asadi
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COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Existence of minimizers in restricted Hartree-Fock theory
Electronic Journal of Differential Equations, 2014 In this note we establish the existence of ground states for atoms within several restricted Hartree-Fock theories. It is shown, for example, that there exists a ground state for closed shell atoms with N electrons and nuclear charge $Z \geq N-1 ...
Fabian Hantsch
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Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Girum's Theory of ḤəluwnätThe Supreme Theory of Existence and Non-Existence
This manuscript presents a unified mathematical framework explaining persistence across all scales—from proteins to cosmology. The framework derives a universal constant α ≈ 1.48 governing regulatory burden scaling and introduces the Viability Ratio VR = M/(dD/dt + εR) as the fundamental measure of persistence capacity.The work resolves major ...
openaire +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
The Explanation of the Theory of Over Abstraction- Intellectuality of the Soul in Molla Sadra’s Viewpoint and Its Ontological Principles [PDF]
حکمت صدرایی, 2013 The theory of over abstraction- intellectuality of the soul, according to Molla Sadra, is the abstraction of the soul from the essence in addition to its abstraction from matter.
Eynollah Khademi, Sayyed Ali Razizadeh
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