Results 71 to 80 of about 101,859 (316)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Existential Boredom Re-examined
, 2019 This paper takes issue with interpretations of boredom as an existential mood that must be avoided. Through addressing some of the inconsistencies in Heidegger’s account of boredom, and relatedly exploring its intricate relationship with nothingness ...
Gilliam, Christian
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تحقیقات نظام سلامت, 2020 Background: This study is conducted with the aim of determining the effectiveness of spiritual-based existential therapy and positive existential therapy on resiliency of elderly women. Methods: The present study was a quasi-experimental study with three
Afsaneh Sartipzadeh +2 more
doaj
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
, 2003 This article explores a range of contributions that existential thinking may be able to make to the theory and practice of person-centred and experiential therapy.
Cooper, Mick; id_orcid, Cooper, Mick
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The need for a new narrative in an era of systemic existential threats [PDF]
, 2022 This contributing paper aims to assess how risk, as generally used and developed over several centuries, may not appropriate for the complex systemic and cascading threats now being faced.
UNDRR
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FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Human Security and Existential Threats: A Governance Framework for Planet, Peace, People & Prosperity [PDF]
, 2023 A key priority for Human Security in the 21st Century is the prevention of existential threats to human civilisation to ensure the well-being of our future generations.
Joanna Nurse
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Educational Theory, 2023 AbstractIn this paper, Kate Kirkpatrick argues that the recent return to moral exemplars in exemplarist moral theory might benefit from engaging with existentialists' use of exemplars in two ways: first, by considering the role of negative exemplars and the power of emotions other than admiration in moral formation; and second, by considering ...
openaire +2 more sources
The human gut microbiome across the life course
FEBS Letters, EarlyView.Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero +4 more
wiley +1 more source