Results 81 to 90 of about 101,859 (316)

Significant events in existential psychotherapy: The client’s perspective [PDF]

open access: yes, 2012
Three ex-clients were interviewed about significant events occurring within existential therapy. Data was analysed through a descriptive phenomenological method (Giorgi, 2009).
Sousa, Daniel Cunha Monteiro de   +2 more
core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

On the succinctness of query rewriting over shallow ontologies [PDF]

open access: yes, 2014
We investigate the succinctness problem for conjunctive query rewritings over OWL2QL ontologies of depth 1 and 2 by means of hypergraph programs computing Boolean functions. Both positive and negative results are obtained.
Podolskii, Vladimir   +8 more
core   +1 more source

WILL TO TRUTH IN THE PHILOSOPHY OF PRAGMATISM

open access: yesAntropologìčnì Vimìri Fìlosofsʹkih Doslìdžen', 2017
Purpose. Since the clear statement of the will-to-truth question as an existential has not been fulfilled before, this article is devoted to the solution of such a task.
D. Y. Snitko
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

“Nothing Sacred”: Violence, Time and Meaning in the Cinema of Possibilities

open access: yesReligions, 2017
Hemingway’s disenchantment with the idea of the sacred as expressed in A Farewell to Arms became a defining aspect of the modern experience including in some Hollywood films such as Nothing Sacred and Twentieth Century.
Sam B. Girgus
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Author Correction: Digital twins: a stepping stone to achieve ocean sustainability?

open access: yesnpj Ocean Sustainability, 2023
Asaf Tzachor   +2 more
doaj   +1 more source

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