Results 91 to 100 of about 101,859 (316)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Timpul parusiei în învățăturile lui Isus Hristos (partea I)
TheoRhēma, 2019 In parallel with the formation of millennial dreams in Europe and America, the 19th century witnessed how rationalism, secularism, and skepticism permeated NT studies, including eschatology. The quest for the historical Jesus revealed a non-supernatural
Laurențiu Florentin Moț
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Existential Humanistic Paradigm in Girish Karnad’s ‘’Hayavadana’’
, 2019 This paper attempts to interrogate Girish Karnad s Hayavadana from the perspective of existentialism relating the protagonist to main concerns of existential paradigm such as freedom choice responsibility finitude and death Individual s ...
Chandra Shekhar Dubey
core
Between Existentialism and Anti-Existentialism
WISDOM, 2022 The article is an evaluation of Pollock’s anti-existentialist argument and its place in the contemporary debates about Existentialism. We demonstrate that the main contemporary objections to Pollock’s Anti-Existentialism can be grouped into two argumentative directions: (1) Pollock’s supposed confusion of inner and outer truth (Fine, Speaks); (2 ...
openaire +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Existential Counselling Primer
, 2012 A brief, accessible introduction to the theory and practice of existential counselling and ...
Cooper, Mick, Cooper, Michael; id_orcid
core
Aristotle and Lukasiewicz on existential import
, 2015 This work was initially supported by Research Grant AH/F018398/1 (Foundations of Logical Consequence) from the Arts and Humanities Research Council, UK.Jan Lukasiewicz's treatise on Aristotle's Syllogistic, published in the 1950s, has been very ...
Read, Stephen, Stephen Read
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source