Results 101 to 110 of about 101,859 (316)
Existential Boredom Re-examined
, 2013 This paper takes issue with interpretations of boredom as an existential mood that must be avoided. Through addressing some of the inconsistencies in Heidegger’s account of boredom, and relatedly exploring its intricate relationship with nothingness ...
Gilliam, Christian
core
Global Security: Health, Science and PolicyFrontier large language models (LLMs) may affect biosecurity both by lowering barriers to biological weapons acquisition and by strengthening clinical preparedness.
Richard C. Armitage
doaj +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Trauma & Resilience: Intergenerational Holocaust research from an existential perspective
, 2018 Respondent E2G2 is de zoon van een halfzus van respondent E1G1. Hij heeft geen contact met gezinsleden; dit is een pijnlijk onderwerp voor hem. Hij gaat met het gemis om door contacten op andere plekken te zoeken, bijvoorbeeld bij vrienden en andere ...
Schuhmann, dr. C.M. (Universiteit voor Humanistiek) +1 more
core +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Probabilities, methodologies and the evidence base in existential risk assessments [PDF]
, 2018 This paper examines and evaluates a range of methodologies that have been proposed for making useful claims about the probability of phenomena that would contribute to existential risk. Section One provides a brief discussion of the nature of such claims,
Rowe, Thomas, Beard, Simon
core
You Sluice and hai Modification in Chinese
Studies in Chinese Linguistics, 2017 This paper argues that you ‘have’ sluice is a variant of pseudosluicing, akin to shi ‘be’ sluice in Chinese. You sluice can be analyzed as a base-generated structure [pro you ‘have’ wh-phrase], consisting of a subject pro, a verb you ‘have’, and a wh ...
Wei Ting-Chi
doaj +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source