Results 91 to 100 of about 22,124,873 (289)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
BMC NursingBackground Emergency rooms prioritize rapid, life-saving interventions, often at the expense of patients’ psychosocial and existential needs. Patients in these settings are particularly vulnerable, yet such needs are frequently overlooked.
Veronica Pavedahl +2 more
doaj +1 more source
Religie & SamenlevingThis article explores existential well-being: the interplay between existential meaning and well-being. It is part of a research project that aims to offer an existential perspective on the declining well-being among Dutch adolescents and young adults ...
Marije Verkerk
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Fundamental Personal Motivations Cornerstone of Existence
Revista de Psicología, 2019 In compliance with the Existential Analysis, the development and the personal realization depend on the success attained when confronting the “Existential Issues” of life.
Alfried Längle
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
EikasíaStrictly speaking, it cannot be said that the field of psychiatry in our country has accustomed us to great publishing surprises. This year, however, autumn has gifted us with magnificent news: the first Spanish edition of the classic text On the Flight ...
Jose González Calvo
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Process and outcome research in existential psychotherapy
, 2016 This study aims to be a contribution to both process and outcome research regarding existential psychotherapy having used, respectively, Psychotherapy Process Q-Set and Clinical Outcomes in Routine Evaluation – Outcome Measurements.
Fernandes, Sandra +6 more
core +1 more source