Results 111 to 120 of about 197,200 (292)
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Ethno-Spirituality: A Postcolonial Problematic? [PDF]
, 2009 This article explores the nature of spirituality in African traditions, for which we use the term ethno-spirituality. We examine the assumptions and effects of western missionaries, and how African spirituality negotiated with these new ideas and merged ...
Bigger, Stephen
core
The No Self View and the Meaning of Life [PDF]
, 2018 Several philosophers, both in Buddhist and Western philosophy, claim that the self does not exist. The no-self view may, at first glance, appear to be a reason to believe that life is meaningless.
Le Bihan, Baptiste
core +2 more sources
The practice of dealing with existential questions in long-term elderly care
International Journal of Qualitative Studies on Health & Well-Being, 2018 Purpose: Existential questions concerning life and death or meaning in life are very salient for many older people receiving long-term care. However, little is known about how long-term care organizations deal with existential issues.
Wander van der Vaart +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
European Journal of Mental Health, 2017 Our research is based on the literature that shows meaningfulness is a correlate of mental health both in the general population and in the case of patients with a serious illness such as cancer.
Szende Elekes
doaj
Argumentative Strategies Against Bradley’s Regress [PDF]
In this paper I will examine the infinite regress arguments pertaining to the unreality of relations that are presented in Francis Herbert Bradley’s paper, Appearance and Reality. Then I will suggest two argumentative strategies one can take to undermine
Woo, Joshua
core
, 2013 This paper is concerned with semantic noun phrase typology, focusing on the question of how to draw fine-grained distinctions necessary for an accurate account of natural language phenomena.
Farkas, Donka F.
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source