FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
Hopelessness, Presence of Meaning in Life, and Existential Concern: A Latent Profile Analysis
Psikiyatride Güncel YaklaşımlarObjective: The present study uses the variables of hopelessness, the presence of meaning in life, and existential concern to obtain a broad conceptualization of suicide risk and aims to uncover distinct latent subgroups formed by these variables. It also
Mehmet Sarıçalı, Ersoy Çarkıt
doaj +1 more source
Encountering existential loneliness among older people: perspectives of health care professionals
International Journal of Qualitative Studies on Health & Well-Being, 2018 Purpose: Existential loneliness is part of being human that is little understood in health care, but, to provide good care to their older patients, professionals need to be able to meet their existential concerns.
Malin Sundström +3 more
doaj +1 more source
Participatory action research, sacred existential epistemology, the eighth moment of qualitative research and beyond… [PDF]
, 2008 [Abstract]: This paper discusses how, in a doctoral study, a collaborative methodology employing Participatory Action Research was embraced, upholding respectful relationships and partnerships that generated co-construction of change in two preschool ...
Hawkins, Karen
core
Standing on the Shoulders of Giants: Exploring the Intersection of Philosophy and HCI:(Accepted workshop) [PDF]
, 2019 The aim of this one-day workshop is to provide a forum for HCI researchers to discuss a wide range of issues at the intersection of philosophy and HCI.
Bardzell, Jeff +5 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
European Journal of General Practice, 2017 Background: General practice recognizes the existential dimension as an integral part of multidimensional patient care alongside the physical, psychological and social dimensions.
Elisabeth Assing Hvidt +11 more
doaj +1 more source
Working to Recover the Essence of Education for the Sake of Teaching and Teacher Education: Towards a Phenomenological Understanding of the Forgotten, Ontological Aspects of Learning [PDF]
, 2011 The current definition of a good teacher is grounded in sets of pre-determined competencies established and imposed upon schools by bureaucratic organizations that are, proximally and for the most part, removed from the foundational elements of education,
Magrini, James
core +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Emotional Impact of Evil: Philosophical Reflections on Existential Problems [PDF]
, 2019 In The Brothers Karamazov, Dostoyevsky illustrates that encounters with evil do not solely impact agents’ beliefs about God (or God’s existence). Evil impacts people on an emotional level as well.
Colgrove, Nicholas
core +1 more source