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Existencialismus v Řezáčově Svědkovi

Česká Literatura
This study deals with existential elements in The Witness, a novel by Václav Řezáč. Its aim is to find and analyse these elements, to reveal the connection between this work by Václav Řezáč and the existentialist thought system, and ...
Anna Šetková
doaj   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Existential Meaninglessness and Meaningfulness in Rebecca West’s the Return of the Soldier: An Existential Psychotherapeutic Study

Zanco Journal of Humanity Sciences
The quest for meaning in life has always constituted a big portion of literature. Having Existential dimensions that investigate the big questions of human existence such as death, isolation, freedom and meaning, some literary works like Rebecca West’s ...
Bukhari Abdullah Rasool, Juan Abdullah Ibrahim   +1 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Existential Wh-Constructions

, 2017
Existential wh-constructions are wh-constructions that have a nominal distribution, an existential (indefinite) meaning, and the superficial appearance of a “bare” wh-clause. They come in two main subtypes—existential free relatives and modal existential wh-constructions—with opinions divided as to how these types are related to each other and whether ...
openaire   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Mythopoeia of the new flu. Event, myth and politics in the Spanish press / Mitopoiesis de la “Gripe Nueva”. Acontecimiento, mito y política en la prensa española

Barataria, 2013
The analysis of the social emergence of new influenza during the spring of 2009, its development and its disappearance contains several elements reluctant to socio-anthropological look. It emerges as an "event".
Jaime de la Calle Valverde
doaj   +1 more source

Existential Constructions in Turkish

RumeliDE Dil ve Edebiyat Araştırmaları Dergisi, 2019
The purpose of this paper is to investigate existential constructions in Turkish. The focus will be on the semantic, discourse as well as structural properties of Noun Phrases (NPs henceforth) in these structures. It is well-attested that there are different types of NPs such as bare NPs, singular and plural indefinite NPs that can serve as pivots in ...
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source