Results 61 to 70 of about 8,575 (295)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Woman Construct: An Existential Critique

SOCRATES, 2015
Cite CHAKRABORTY, A., & DAS, P. (2015). The Woman Construct: An Existential Critique. S O C R A T E S, 2(4), 13-20. Retrieved from http://www.socratesjournal.com/index.php/socrates/article/view/19 REFERENCES Chaudhuri, S. (2006). Feminist Film Theorists: Laura Mulvey, Kaja Silverman, Teresa de Lauretis, Barbara Creed. Routledge.
Arghya, Chakraborty, Pinaki Ranjan, Das
openaire   +2 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Existential constructions : In search of a definition

, 2023
International audienceSince the first formulation by Jespersen, the existential construction has neverceased to interest linguists, who have offered an increasingly fine-grained pictureof its properties. The contributions to this volume shed new light on
Sarda, Laure, Lena, Ludovica
core  

Presentative Constructions in English and Lithuanian

Kalbotyra, 2002
The article focuses on the type of existential sentence which is known in linguistic literature as a presentative construction. This type is distinguished on functional grounds: its communicative function is to introduce a new entity into a discourse. In
Violeta Kahėdaitė
doaj  

Existencialismus v Řezáčově Svědkovi

Česká Literatura
This study deals with existential elements in The Witness, a novel by Václav Řezáč. Its aim is to find and analyse these elements, to reveal the connection between this work by Václav Řezáč and the existentialist thought system, and ...
Anna Šetková
doaj   +1 more source

Existential Constructions in Turkish

RumeliDE Dil ve Edebiyat Araştırmaları Dergisi, 2019
The purpose of this paper is to investigate existential constructions in Turkish. The focus will be on the semantic, discourse as well as structural properties of Noun Phrases (NPs henceforth) in these structures. It is well-attested that there are different types of NPs such as bare NPs, singular and plural indefinite NPs that can serve as pivots in ...
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

The syntax of existential sentences in Serbian

, 2008
Freeze (1992) argued on the basis of data from several different languages that there is a close relationship between existential sentences (stating the existence of an entity) and locative sentences (stating the location of an entity).
Milicevic, Nataša, Hartmann, Jutta M.
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