Results 81 to 90 of about 8,575 (295)

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Conceptualization, Construction and Validation of the Existential Fulfilment Scale [PDF]

open access: yes, 2007
research articleThis study presents the development and validation of the Existential Fulfilment Scale. Following Frankl’s concepts of life meaning and existential vacuum, the authors elaborate the construct of existential fulfilment.
Brouwers, A., Tomic, W., Loonstra, B.
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Syntactic and FSP aspects of the existential construction in Norwegian

open access: yes, 2014
The aim of the present thesis is to analyze the Norwegian existential construction (presenteringskonstruksjonen) with regard to syntax, static semantics, dynamic semantics, and functional sentence perspective (FSP).
Dubec, Pavel
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Attribute-Based Signcryption: Signer Privacy, Strong Unforgeability and IND-CCA Security in Adaptive-Predicates Model (Extended Version) [PDF]

open access: yesJournal of Internet Services and Information Security, 2016
Attribute-Based Signcryption (ABSC) is a natural extension of Attribute-Based Encryption (ABE) and Attribute-Based Signature (ABS), where one can have the message confidentiality and authenticity together. Since the signer privacy is captured in security
Tapas Pandit   +2 more
doaj  

Existential arithmetization of Diophantine equations

open access: yes, 2009
A new method of coding Diophantine equations is introduced. This method allows (i) checking that a coded sequence of natural numbers is a solution of a coded equation without decoding; (ii) defining by a purely existential formula, the code of an ...
Matiyasevich, Yuri
core   +1 more source

Le syntagme « existentiel » en breton : définition syntaxique et sémantique

open access: yesLa Bretagne Linguistique, 1989
In Breton, the construction of a so-called "existential" statement clearly involves the verb bezañ "to be" in its two forms zo and eus (avel a zo ; n’eus ket avel: "there is wind; there is no wind").
Jean-Yves Urien
doaj   +1 more source

How phagocytic cells kill bacteria: Lessons from a professional killer

open access: yesFEBS Open Bio, EarlyView.
How phagocytic cells ingest and kill bacteria has been studied for more than a century, but many questions remain unanswered. The study of the amoeba Dictyostelium discoideum brings new answers, and new questions. Professional phagocytic cells such as neutrophils and macrophages, as well as free‐living soil amoebae like Dictyostelium discoideum, employ
Otmane Lamrabet, Pierre Cosson
wiley   +1 more source

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