Results 61 to 70 of about 655,566 (261)

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

L‐aspartate oxidase provides new insights into fumarate reduction in anaerobic darkness in Synechocystis sp. PCC6803

FEBS Letters, EarlyView.
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil, Jeffrey A. Hawkes, Cecilia Blikstad, Pia Lindberg   +3 more
wiley   +1 more source

Kappa-Join: Efficient Execution of Existential Quantification in XML Query Languages [PDF]

, 2006
XML query languages feature powerful primitives for formulating queries, involving comparison expressions which are existentially quantified. If such comparisons involve several scopes, they are correlated and, thus, become difficult to evaluate efficiently.
Brantner, Matthias, Helmer, Sven, Kanne, Carl-Christian, Moerkotte, Guido   +3 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Materialisation of existential aesthetics

, 2023
Maes’ proposal on existential aesthetics, which appeared in the Journal of Aesthetics and Art Criticism in 2022, has the potential to be extended in myriad manners. Here, the attempt is to confer a material or tangible extension to his proposal. Material
Khetrapal, Neha
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Existential Choice: Husserl Meets Heller

, 2022
In this paper, I develop a vindication of Agnes Heller’s conception of existential choice by drawing on Husserl’s manuscripts and lectures on ethics. In the !rst two sections, I reconstruct Heller’s view and the criticism that has been raised against ...
Staiti Andrea Sebastiano
core   +1 more source

Quantification and Negation in Event Semantics

The Baltic International Yearbook of Cognition, Logic and Communication, 2010
Recently, it has been claimed that event semantics does not go well together with quantification, especially if one rejects syntactic, LF-based approaches to quantifier scope.
Lucas Champollion
doaj   +1 more source

Tuvan <em>-daa</em> in quantificational noun phrases: Existential or universal?

Proceedings of the Linguistic Society of America, 2022
This paper characterizes the main functions of the Tuvan particle -daa and proposes a semantic analysis, focusing on its role in Quantificational NPs (QNPs), specifically its role in forming Negative Polarity Items (NPIs) and universal quantifiers.  It is argued that Tuvan -daa QNPs are underlyingly existentials, with these two main readings being ...
openaire   +1 more source