Results 91 to 100 of about 61,755 (265)

Mitigating the negative impact of new buildings on existing buildings' user comfort-a case study analysis. [PDF]

Simulation, 2023
Rajus VS, Risopatron NA, O'Brien W, Wainer G, Fai S.   +4 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Buckling stability analysis of underpinning piles during basement excavation beneath existing buildings. [PDF]

Sci Rep, 2022
Shan H, Yang J, Hu Z, He S.
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Modification of partial safety factors for a semi-probabilistic evaluation of existing timber structures

Engineering Structures and Technologies
The evaluation of the load-bearing capacity of existing structures is a central and important part in the work of structural engineers. Currently, engineers are confronted with the challenge of applying design rules developed for new structures in the ...
Maria Loebjinski, Zheng Li, Wolgang Rug, Hartmut Pasternak   +3 more
doaj   +1 more source

Experiment dataset of dynamic properties of damper material derived from automotive spare parts as passive control devices for retrofitting existing buildings. [PDF]

Data Brief, 2023
Nurchasanah Y, Suhendro B, Satyarno I.
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Existing Buildings Recognition and BIM Generation Based on Multi-Plane Segmentation and Deep Learning

Buildings
Point cloud-based BIM reconstruction is an effective approach to enabling the digital documentation of existing buildings. However, current methods often demand substantial time and expertise for the manual measurement of building dimensions and the ...
Dejiang Wang, Jinzheng Liu, Haili Jiang, Panpan Liu, Quanming Jiang   +4 more
doaj   +1 more source

Raspberry Shake-Based Rapid Structural Identification of Existing Buildings Subject to Earthquake Ground Motion: The Case Study of Bucharest. [PDF]

Sensors (Basel), 2022
Özcebe AG, Tiganescu A, Ozer E, Negulescu C, Galiana-Merino JJ, Tubaldi E, Toma-Danila D, Molina S, Kharazian A, Bozzoni F, Borzi B, Balan SF.   +11 more
europepmc   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source