Results 81 to 90 of about 61,755 (265)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Experimental Characterization, Modeling, and Numerical Evaluation of a Novel Friction Damper for the Seismic Upgrade of Existing Buildings. [PDF]

Materials (Basel), 2023
Bruschi E, Zoccolini L, Cattaneo S, Quaglini V.   +3 more
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Importance of Dynamic Evolving Architecture

Ardeth
Broken World thinking encourages us to view existing buildings through a new lens, shifting our focus on sustainability from absolute measures like carbon emissions and energy consumption to circularity within the built environment. Existing and historic
James Ritson
doaj  

A review of facilities management interventions to mitigate respiratory infections in existing buildings. [PDF]

Build Environ, 2022
Zhang Y, Hui FKP, Duffield C, Saeed AM.
europepmc   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Preliminary Study on Measures to Improve Fire Safety in Existing High-Rise Residential Buildings with Combustible Façades

Buildings
The tragic fires at the Grenfell Tower (London, UK) in 2017 and the building in the Campanar neighbourhood (Valencia, Spain) in 2024, among other fires, occurring in existing high-rise residential buildings with combustible façades, have prompted a ...
Teresa Escrig, Teresa Soto, Begoña Serrano-Lanzarote, Alejandra García-Prieto Ruiz   +3 more
doaj   +1 more source

Green and Energy-Saving Ecological Reconstruction Design of Existing Buildings in Cities in Severe Cold Areas. [PDF]

J Environ Public Health, 2022
Zhang H, Yang T.
europepmc   +1 more source

Risk assessment and retrofit of existing buildings

Bulletin of the New Zealand Society for Earthquake Engineering, 2000
The structural risk assessment and evaluation process is broken into the steps of Develop knowledge of as-built conditions, Determine local response characteristics, Create mathematical model, Perform global analysis, Determine acceptability, and Select retrofit procedure/Classify per evaluation procedure and each step discussed.
openaire   +2 more sources

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source