Results 61 to 70 of about 61,755 (265)
A Review on Conversion of Existing Building into Green Building
INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT, 2022 Green building construction has resulted in a slew of inventive solutions to lower energy usage. The requirement to develop a unified dimensional model for resource-saving, and environmentally friendly is a problem for assessments of green renovation (GR) of existing structures. India has three mechanisms viz.
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
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Existing buildings retrofit through multiobjective optimization: a case-study
Tema, 2018 In the light of the regulations on buildings energy performance, the designers face the need to choose among alternative design solutions, having to assess their effectiveness according to several -sometimes conflicting- points of view, such as the ...
Elisa Di Giuseppe +3 more
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
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Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
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‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
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Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
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BuildingsThe seismic rehabilitation of existing buildings has become a major challenge in structural engineering due to the ageing of the global building stock, increasing seismic risk, and the growing demand for sustainable and resilient infrastructure. Although
Dorina Nicolina Isopescu +2 more
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Smart building technologies in existing buildings
, 2023 The research aimed to explore the potential of Smart technology to reduce heating costs in old-er buildings and to identify the requirements that a building must fulfil to make an upgrade economically reasonable. The study found that integrating Smart Building technology, such as the Internet of Things, Smart Meters and building automation, can ...
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