Results 21 to 30 of about 15,965 (206)

Recent Advances in Mouse Models of Sjögren's Syndrome

Frontiers in Immunology, 2020
Sjögren's syndrome (SS) is a complex rheumatoid disease that mainly affects exocrine glands, resulting in xerostomia (dry mouth) and xerophthalmia (dry eye). SS is characterized by autoantibodies, infiltration into exocrine glands, and ectopic expression
Yunzhen Gao, Yan Chen, Zhongjian Zhang, Xinhua Yu, Junfeng Zheng   +4 more
doaj   +1 more source

Bilateral parotid gland punctate calcifications in Sjögren's Syndrome: a case report

Radiology Case Reports, 2022
Sjögren's syndrome is a chronic autoimmune disorder characterized by mononuclear infiltration of exocrine glands, most commonly the lacrimal and salivary glands.
Gabriele Noreikaite, BS, Michael L Toscano, DO, Carl B. Shermetaro, DO   +2 more
doaj   +1 more source

In situ patrolling of regulatory T cells is essential for protecting autoimmune exocrinopathy. [PDF]

PLoS ONE, 2010
BACKGROUND: Migration of T cells, including regulatory T (Treg) cells, into the secondary lymph organs is critically controlled by chemokines and adhesion molecules.
Naozumi Ishimaru, Takeshi Nitta, Rieko Arakaki, Akiko Yamada, Martin Lipp, Yousuke Takahama, Yoshio Hayashi   +6 more
doaj   +1 more source

UHFUS: A Valuable Tool in Evaluating Exocrine Gland Abnormalities in Sjögren’s Disease

Diagnostics, 2023
Sjögren’s Disease (SjD) is a chronic autoimmune disorder that affects the salivary and lacrimal glands, leading to xerostomia and xerophthalmia. Ultrasonography of Major Salivary Glands (SGUS) is a well-established tool for the identification of the ...
Giovanni Fulvio, Rossana Izzetti, Giacomo Aringhieri, Valentina Donati, Francesco Ferro, Giovanna Gabbriellini, Marta Mosca, Chiara Baldini   +7 more
doaj   +1 more source

Integrated Single‐Nucleus Multi‐Omics Atlases Reveal Lineage Plasticity and Regulatory Networks of Luminal Epithelial Cells During Mammary Gland Lactation and Involution

Advanced Science, EarlyView.
This study integrates single‐cell multi‐omics, spatial transcriptomics, and cross‐species comparative analyses to systematically characterize the cellular composition and differentiation trajectories of goat mammary epithelial cells, along with the gene regulatory networks and intercellular communication mechanisms governing these trajectories, thereby
Xiaoru Yan, Xiaoyu Mi, Guanghui Tan, Xinmei Li, Zhenliang Zhu, Zhenyu Wei, Huimei Fan, Yamei Wu, Tao Shi, Lingzhao Fang, Yuanpeng Gao, Yu Wang, Jun Liu   +12 more
wiley   +1 more source

The involvement of aquaporin 5 in the inflammatory response of primary Sjogren’s syndrome dry eye: potential therapeutic targets exploration

Frontiers in Medicine
Sjogren’s syndrome (SS) is a chronic autoimmune disease. Mainly due to the infiltration of lymphoplasmic cells into the exocrine glands, especially the salivary glands and lacrimal glands, resulting in reduced tear and saliva secretion. Reduced tear flow
Lijuan Fu, Lijuan Fu, Zihang Zhao, Zihang Zhao, Shuang Zhao, Shuang Zhao, Meiying Zhang, Xiaoming Teng, Xiaoming Teng, Liyuan Wang, Liyuan Wang, Tiansong Yang   +11 more
doaj   +1 more source

Histoanatomical study on pancrease of mature river buffalo [PDF]

Āsīb/shināsī-i Darmāngāhī-i Dāmpizishkī, 2012
Pancreas gland is one of large glands related with digestive duct. This gland consists of exocrine and endocrine parts. In this article, 10 pancrase glands of buffalo with surrounding tissues and duodenum were prepared and studied anatomically and ...
M.A Ebrahimi, H Javidfar
doaj  

Rectal, Anal Gland: A Corrective Morphological Study in New Zealand Rabbit (Oryctolagus cuniculus) [PDF]

Benha Veterinary Medical Journal, 2018
In order to achieve the main objective of our research is to prove that rabbits possess rectal glandsnot anal glands. Our work was carried out on fifteen healthy adult New Zealand rabbits(Oryctolagus cuniculus) of both sexes and with variable ages.
Sozan Ali, Hanaa El-Ghazali
doaj   +1 more source

Polystyrene Nanoplastics Drive β‐Cell Dedifferentiation Through Dendritic Cell‐Intrinsic MHC‐I‐Dependent Inflammatory Crosstalk

Advanced Science, EarlyView.
Polystyrene nanoplastics disrupt pancreatic immune–endocrine homeostasis by promoting MHC‐I‐associated dendritic cell activation and inflammatory crosstalk with β cells. This immune remodeling drives β‐cell dedifferentiation, impairs insulin secretion, and aggravates metabolic dysfunction, revealing a previously unrecognized immunometabolic mechanism ...
Conghui Qiao, Yuqing Song, Fang Yang, Menghui Guo, Libin Jiang, Xiaoyue Quan, Wei Wei, Xinyang Wang, Tianshu Han, Mingyuan Liu, Wenbo Jiang   +10 more
wiley   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source