Results 111 to 120 of about 838,049 (387)

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Extraction and Purification of Melanin from Different Sources and Tissues

Exon
Melanins are phenolic biopolymers synthesized by most of the living organism mainly for photoprotection or surviving in harsh conditions. Melanin is localized in different areas or complexed with different other biomolecules when observed from animals to
Noble K Kurian
doaj   +1 more source

Multiple Myeloma Patient Tumors With High Levels of Cereblon Exon-10 Deletion Splice Variant Upregulate Clinically Targetable Pro-Inflammatory Cytokine Pathways

, 2022
Kübra Karagoz, Matthew P. Stokes, María Ortiz-Estévez, Fadi Towfic, Erin Flynt, Sarah Gooding, William E. Pierceall, Anjan Thakurta   +7 more
openalex   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source

Single Nucleotide Polymorphisms: A Deep Consideration of Protein Sequence Variation [PDF]

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd
Introduction: Human genome consists of the three billion base pairs that has about one percent of genetic variation from one person to another، which determines physical، psychological، and susceptibility to diseases. Among the types of genetic diversity,
Majid Marzban Sarnaghi, Deniz Farzad, Reza Gholikhani Darbroud, Zafar Gholinejad   +3 more
doaj  

Assessment of Proximate, Mineral and amino acid Profile of Selected Agro-Allied By-Products Residues in Umuagwo, Imo State Nigeria

Exon
This study presents the first comparative analysis of proximate, mineral and amino acid composition of selected agricultural crop residues as potential feed ingredients in livestock and poultry production.
JohnPaul Nnawuike Azorji, Ohanusi I, Arodiogbu Francis Uche, Uzowulu Ebere, Okafor Justina Ogbonna, Onyekachi Uju Tilda, Amadi J.E.C   +6 more
doaj   +1 more source

The impact of histopathology and NAB2-STAT6 fusion subtype in classification and grading of meningeal solitary fibrous tumor/hemangiopericytoma. [PDF]

, 2019
Meningeal solitary fibrous tumor (SFT)/hemangiopericytoma (HPC) is a rare tumor with propensity for recurrence and metastasis. Although multiple classification schemes have been proposed, optimal risk stratification remains unclear, and the prognostic ...
Alexander, Brian M, Brastianos, Priscilla K, Brat, Daniel, Brown, Paul D, Caron, Alissa, Ferrarese, Fabio, Fritchie, Karen, Giannini, Caterina, Guajardo, Andrew, Haller, Florian, Jenkins, Sarah, Jensch, Kassandra, Kaplan, Alexander, Link, Michael, Louis, David N, Moskalev, Evgeny A, Perry, Arie, Raleigh, David R, Rodriguez, Fausto J, Rossi, Sabrina, Santagata, Sandro, Velázquez Vega, José E, Wu, Ashley   +22 more
core  

STAT1 activation in association with JAK2 exon 12 mutations [PDF]

, 2015
La inclusión de la perspectiva de género en la actividad jurisdiccional es una demanda sostenida de los colectivos feministas y de mujeres, dado que las sentencias tienen un poder performativo y envían un mensaje a la sociedad: “[…] tienen un poder ...
Godfrey, A.L., Chen, E., Massie, C.E., Silber, Y., Pagano, F., Bellosillo, B., Guglielmelli, P., Harrison, C.N., Reilly, J.T., Stegelmann, F., Bijou, F., Lippert, E., Boiron, J.M., Dohner, K., Vannucchi, A.M., Besses, C., Green, A.R., Godfrey, A.L., Chen, E., Massie, C.E., Silber, Y., Pagano, F., Bellosillo, B., Guglielmelli, P., Harrison, C.N., Reilly, J.T., Stegelmann, F., Bijou, F., Lippert, E., Boiron, J.M., Dohner, K., Vannucchi, A.M., Besses, C., Green, A.R.   +33 more
core   +4 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Sustainable Conversion of Chitosan Waste into Nitrogen-Doped Graphene Quantum Dots: Green Synthesis Pathways and Biomedical Potential

Exon
The sustainable conversion of bio-waste into functional nanomaterials represents a critical step toward achieving circular material cycles and environmentally responsible innovation.
B Sooryakanth, M R Rajan, S Sudhabose, Sangeetha Arulalan, Brindha B, Ruthra R, Shakila Venkatesan, Aswathy V   +7 more
doaj   +1 more source