Results 101 to 110 of about 838,175 (338)

Implementing One Health approach to emerging zoonotic diseases: Bridging surveillance, sustainability and global governance

Exon
The One Health approach offers a pragmatic and policy-relevant framework that integrates human, animal, and environmental health systems to confront the rising threat of zoonotic diseases.
Kingsley Excel Dunga, Chinyere Ihuarulam Okoro, Amarachi Chisom Onyenama, Uchechukwu Onyeukwu Ekuma, Irene Nneka Ohanusi, Sylvester Chibueze Izah   +5 more
doaj   +1 more source

Genomic Organization, Splice Variants and Expression of CGMl, a CD66-related Member of the Carcinoembryonic Antigen Gene Family [PDF]

, 1993
The tumor marker carcinoembryonic antigen (CEA) belongs to a family of proteins which are composed of one immunogiobulin variable domain and a varying number of immunoglobulin constant-like domains.
Afar D. E. H., Audette M., Baniyash M., Berling B., Culic O., Elsen P., Felgner P. L., Fiddes J. C., Knapp W., Kolbinger F., Kuroki M., Kuroki M., Kuroki M., Lin S.-H., Lucas K., Margolis R. N., McCuaig K., Nap M., Neumaier M., Ng S. Y., Oikawa S., Oikawa S., Paxton R., Pelegrin A., Raskind W. H., Rojas M., Sambrook J. E., Schwarz K., Shively J. E., Skubitz K. M., Southern P. J., Thompson J. A., Thompson J. A., Turbide C., Tynan K., Watt S. M., Woodgett J. R., Zhou H.   +37 more
core   +2 more sources

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Nanotechnology and Biotechnology Against Multidrug-Resistant Pathogens: Promises and Challenges

Exon
The escalating threat of multidrug-resistant (MDR) pathogens necessitates innovative strategies that transcend conventional antibiotic paradigms. This review explores the transformative potential of integrating nanotechnology and biotechnology to address
Saad Ahmed
doaj   +1 more source

Characterization of two new alleles at the goat CSN1S2 locus. [PDF]

, 2001
Two novel alleles at the goat CSN1S2 locus have been identified: CSN1S2(F) and CSN1S2(D). Sequence analyses revealed that the CSN1S2(F) allele is characterized by a G --> A transition at the 13th nucleotide in exon 3 changing the seventh amino acid of ...
COSENZA, GIANFRANCO, DI GREGORIO P, GALLO, DANIELA, LONGOBARDI E, PAPPALARDO, MARGHERITA, PASTORE N, RAMUNNO, LUIGI, RANDO A.   +7 more
core   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

In vitro Antibacterial Activity and Phytochemical Profiling of Selected Medicinal Plants

Exon
This study aimed to investigate the phytochemical composition and antimicrobial activity of five Indian medicinal plants: Azadirachta indica, Mangifera indica, Ocimum tenuiflorum, Solanum trilobatum, and Piper betle, which were selected for their ...
Mohamed Shafil S, R Sriram, Syed Raffic Ali S, Md. Azmathullah N, Ghani Basha K, Sultan Mohideen A. K   +5 more
doaj   +1 more source

Detecting differential usage of exons from RNA-Seq data [PDF]

, 2012
RNA-Seq is a powerful tool for the study of alternative splicing and other forms of alternative isoform expression. Understanding the regulation of these processes requires comparisons between treatments, tissues or conditions.
Alejandro Reyes, Simon Anders, Wolfgang Huber   +2 more
core   +3 more sources

Accurate clinical detection of exon copy number variants in a targeted NGS panel using DECoN

Wellcome Open Research, 2016
Background: Targeted next generation sequencing (NGS) panels are increasingly being used in clinical genomics to increase capacity, throughput and affordability of gene testing.
Anna Fowler, S. Mahamdallie, Elise Ruark, S. Seal, Emma Ramsay, M. Clarke, I. Uddin, Harriett Wylie, Ann Strydom, G. Lunter, N. Rahman   +10 more
semanticscholar   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source