Results 81 to 90 of about 404,647 (255)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Bioinformatics Approaches for Integrating Clinical and Environmental Data to Enhance Machine Learning Based Diabetes Risk Prediction

Exon
Diabetes is due to a variety of interacting factors including behavioral, metabolic and environmental ones. The large number of biomedical data collected in an increasingly multi-modal manner has given rise to many potential methods in bioinformatics to ...
Houda Harbaoui, Hela Harbeoui, Moufida Saidani Tounsi   +2 more
doaj   +1 more source

A 57‐Year‐Old Male With Behavioral Variant Frontotemporal Dementia and MATR3 and NOS3 Mutations

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT This report presents a case of behavioral variant frontotemporal dementia caused by mutations in the MATR3 and NOS3 genes, aiming to analyze its clinical manifestations and genetic characteristics. For a case presenting with personality changes and gait abnormalities as the initial symptoms, this study conducted a comprehensive analysis of its
Feifei Lin, Saie Huang
wiley   +1 more source

Exploring the Pharmacological Application of Terpenoids in Plasmid Curing

Exon
The World Health Organization [WHO] has identified antimicrobial resistance [AMR] as one of the top ten dangers to world health. By decreasing the effectiveness of antibiotics and making contemporary medical treatments more difficult, it poses serious ...
Suganya Pitchai, Devanam Priya Vinoth Kumar, Ranjith Santhosh Kumar Devanesan Sanjeevi   +2 more
doaj   +1 more source

Blood RNA Biomarker Signatures for Early Diagnosis and Prognosis in Ischemic and Hemorrhagic Stroke: The IBIS‐CT1 Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the expression of nine blood RNA biomarkers in a clinical trial based on genes previously identified in an experimental monkey model of stroke for diagnosis feasibility and prognostication. Methods IBIS‐CT1 was a prospective longitudinal study enrolling patients with ischemic stroke (IS) or intracerebral hemorrhage (ICH ...
Salomé Retailleau, Marie Bruguet, Irina Viakhireva‐Dovganyuk, François‐Mathias Merrien, Denis Marechal, Aurore Jourdain, Philippe Goas, Jordan Coris, Julien Asselineau, Maëlys Consigny, Gérald Le Gac, Serge Timsit   +11 more
wiley   +1 more source

Biodegradation of Petroleum Waste by Actinomycetes: Mechanisms, Applications, and Future Prospects

Exon
Actinomycetes are a specialized group of gram-positive, filamentous bacteria distinguished by their high G-C DNA content and an extraordinary capacity for bioremediation.
Dhruti Parejiya, Vanshi Parmar, Vidhya Maheshwari, Ritesh Tandel   +3 more
doaj   +1 more source

Augmenting and Assaying Nav1.1 Protein Quantity for Dravet Syndrome Therapy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dravet Syndrome (DS) is a developmental and epileptic encephalopathy predominantly caused by heterozygous loss‐of‐function variants in SCN1A, which encodes Nav1.1. Conserved upstream open reading frames (uORFs) in SCN1A were validated to regulate translation in reporter assays, demonstrating the therapeutic viability of increasing Nav1.1 from ...
Aiswarya Saravanan, Jordan Safran, Anna Loughman, Grace Lin, Shivanshi Vaid, Dana Allababidi, Peter M. Tessier, Louis T. Dang   +7 more
wiley   +1 more source

Assessment of Proximate, Mineral and amino acid Profile of Selected Agro-Allied By-Products Residues in Umuagwo, Imo State Nigeria

Exon
This study presents the first comparative analysis of proximate, mineral and amino acid composition of selected agricultural crop residues as potential feed ingredients in livestock and poultry production.
JohnPaul Nnawuike Azorji, Ohanusi I, Arodiogbu Francis Uche, Uzowulu Ebere, Okafor Justina Ogbonna, Onyekachi Uju Tilda, Amadi J.E.C   +6 more
doaj   +1 more source

Transient Cytoskeletal Anisotropy Encodes Short‐Term Mechanical Memory in Glioblastoma Cells

Advanced Materials, EarlyView.
The same mechanical deformation can produce distinct cytoskeletal states depending on loading history. Experiments and constitutive modeling reveal that transient actin–vimentin anisotropy stores mechanical information and governs short‐term mechanical memory in glioblastoma cells.
Clara Gomez‐Cruz, Matthieu Gelin, Lucas Pradeau‐Phélut, Arrate Muñoz‐Barrutia, Sandrine Etienne‐Manneville, Daniel Garcia‐Gonzalez   +5 more
wiley   +1 more source

Sustainable Conversion of Chitosan Waste into Nitrogen-Doped Graphene Quantum Dots: Green Synthesis Pathways and Biomedical Potential

Exon
The sustainable conversion of bio-waste into functional nanomaterials represents a critical step toward achieving circular material cycles and environmentally responsible innovation.
B Sooryakanth, M R Rajan, S Sudhabose, Sangeetha Arulalan, Brindha B, Ruthra R, Shakila Venkatesan, Aswathy V   +7 more
doaj   +1 more source