Results 71 to 80 of about 404,647 (255)

Longitudinal Assessment of Biomarkers in ALS: Discriminative Biomarkers for Disease Progression and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To assess the association and discriminative performance of serum biomarkers with clinical disease progression and survival in patients with amyotrophic lateral sclerosis (ALS). Methods This retrospective study, conducted at Houston Methodist Hospital, Houston, TX, used longitudinal serum samples collected between January 2018 and ...
David R. Beers, Yueh‐Yun Lin, Jason R. Thonhoff, Aaron D. Thome, Alireza Faridar, Weihua Zhao, Shixiang Wen, Stanley H. Appel   +7 more
wiley   +1 more source

In Silico Screening of Phenylpropanoid and Polyketide Phytochemicals as Potential Inhibitors of Mpox Viral Proteins

Exon
Mpox, a viral zoonotic disease similar to smallpox, poses significant public health challenges, particularly in Africa, with recent outbreaks in regions like India emphasising its global threat.
Anishkiran Balasundar, Rajesh Parsanathan   +1 more
doaj   +1 more source

Safety and Tolerability of Givinostat: Evidence From Real‐World and Clinical Practice

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The aim of our study was to establish the prevalence of adverse events in a real‐world setting in boys living with Duchenne muscular dystrophy (DMD) treated with givinostat as part of an Expanded Access Program (EAP) in Italy. Methods The cohort included 90 ambulant boys, with age when treatment started between 6 and 23 years (mean ...
Marika Pane, Anna Capasso, Chiara Arpaia, Adele D’Amico, Emilio Albamonte, Federica Trucco, Maria Sframeli, Riccardo Masson, Francesca Magri, Luca Bello, Romina Venditti, Claudia Dosi, Michela Catteruccia, Michele Tosi, Claudio Bruno, Sonia Messina, Giacomo Comi, Elena Pegoraro, Valeria A. Sansone, Eugenio Mercuri   +19 more
wiley   +1 more source

Edible coatings for enhancing the shelf-life of foods: meaningful or myth

Exon
In the current landscape, effective food management poses significant challenges, particularly in ensuring access to healthy, nutritious diets. Proper handling of food materials during post-harvest stages such as harvesting, packaging, transportation ...
Venkteshwar Yadav, Dharm Pal, Anil Kumar Poonia   +2 more
doaj   +1 more source

Early Clinical, Imaging, and Pathological Characteristics of SRPK3/TTN‐Digenic Myopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective SRPK3/TTN‐digenic myopathy was recently established as a skeletal muscle myopathy caused by digenic inheritance. This study characterizes the early clinical presentation of SRPK3/TTN‐digenic myopathy in one previously reported and seven newly identified pediatric patients.
Rotem Orbach, Sandra Donkervoort, Carola Hedberg‐Oldfors, Giovanni Baranello, Dimah Saade, Precilla D'Souza, Ruchee Patel, Eva Michael, A. Reghan Foley, Diana Bharucha‐Goebel, S. Jin Haugland, Meghan McAnally, Omer Abdul Hamid, Katherine Chao, Ellen F. Macnamara, Alan H. Beggs, Anna Sarkozy, Juliane Mueller, Steven A. Moore, Richard S. Finkel, Cynthia J. Tifft, Francesco Muntoni, Anders Oldfors, Carsten G. Bönnemann   +23 more
wiley   +1 more source

Anthrax the Most Lethal Bioterror: Synthesizing Knowledge and Insights for Researchers and Public Health Professionals

Exon
Anthrax, caused by Bacillus anthracis, poses a significant threat as both, a naturally occurring disease and a potent bioterrorism agent. This article comprehensively reviews anthrax, synthesizing historical context, biological characteristics, past ...
Saad Ahmed, Haris Ishtiaq Kiani
doaj   +1 more source

Compound Heterozygote Friedreich Ataxia Patients With Covert Proximal FXN Gene Deletions

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We present Friedreich ataxia patients with frataxin gene deletions. Data and records were collected at the Children's Hospital of Philadelphia from patients enrolled in the FACOMS natural history study. Patients with proximal deletions initially diagnosed with only one GAA expanded allele had more severe disease than their homozygous expansion
Michael P. Lazaropoulos, Morgan C. Devore, Christina Lam, Courtney Park, Sanjay Bidichandani, David R. Lynch   +5 more
wiley   +1 more source

Ethnobotanical Survey of Medicinal Plants Used in the Treatment of Skin Infections and Arthritis in Bova, Southwest, Cameroon

Exon
Background: According to WHO data published in 2020, the mortality rate from rheumatoid arthritis in Cameroon was 0.01%. Skin infections affect people of all ages, from neonates to the elderly, and account for approximately 34% of all diseases ...
Lifita Victorine Kinge Molonge, Elisabeth Menkem Zeuko'o, Moforcha Lilian Zemenjuh, Eleonore Ngounou, Arnaud Kouam Fondjo, Woquan Sama Luma, Fabrice Fekam Boyom   +6 more
doaj   +1 more source

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni, Cecile Pagan, Antony Citterio‐Quentin, Isabelle Rouvet, Giulia Dingeo, Cyril Hanin, Claudine Laurent‐Levinson, Samia Pichard, Bénédicte Héron, Clément Gourguechon, Daniele Mandia, Jerome Guitton, Carole Lacout, Nicolas Schleinitz, Florient Potier, Olivier Flabeau, Elsa Besse‐Pinot, Foudil Lamari, Magali Pettazzoni, Yann Nadjar   +19 more
wiley   +1 more source

Assessing Public Perception, Awareness, and Knowledge of Biotechnology in Pakistan: Insights from a Cross-Sectional Study

Exon
Aim: This study aims to explore the perceptions, attitudes, and knowledge of the Pakistani population towards biotechnology and to identify the demographic factors influencing these perceptions. Methodology: A cross-sectional survey was conducted from
Saad Ahmed, Hamna Atique, Hafsa Atique, Nida Ishtiaq, Haris Ishtiaq Kiani, Mahum Khan, Muhammad Fahad Shabbir   +6 more
doaj   +1 more source