Results 51 to 60 of about 404,647 (255)

Nanotechnology and Biotechnology Against Multidrug-Resistant Pathogens: Promises and Challenges

Exon
The escalating threat of multidrug-resistant (MDR) pathogens necessitates innovative strategies that transcend conventional antibiotic paradigms. This review explores the transformative potential of integrating nanotechnology and biotechnology to address
Saad Ahmed
doaj   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

In vitro Antibacterial Activity and Phytochemical Profiling of Selected Medicinal Plants

Exon
This study aimed to investigate the phytochemical composition and antimicrobial activity of five Indian medicinal plants: Azadirachta indica, Mangifera indica, Ocimum tenuiflorum, Solanum trilobatum, and Piper betle, which were selected for their ...
Mohamed Shafil S, R Sriram, Syed Raffic Ali S, Md. Azmathullah N, Ghani Basha K, Sultan Mohideen A. K   +5 more
doaj   +1 more source

Evolution‐guided yeast complementation reveals functional differences in human PSPH variants

FEBS Open Bio, EarlyView.
Ancient genomes can help guide which human genetic variants are tested experimentally. This study applies that idea to PSPH, a gene involved in serine biosynthesis, and uses high‐throughput yeast complementation to compare variant function. The findings reveal measurable differences among selected alleles and illustrate the value of evolution‐guided ...
Mauricio Campa‐Álvarez, Diana Ascencio, Miguel Vallebueno‐Estrada, Eduardo González‐Orozco, Christian Eduardo Martínez‐Guerrero, Rafael Montiel, Alexander DeLuna   +6 more
wiley   +1 more source

Phenological Variations and Pharmacological Properties of Cassia Fistula: A Review of Environmental and Therapeutic Dimensions

Exon
The golden shower tree, Cassia fistula, is a botanical symbol of persistence, providing aesthetic appeal and sophisticated ecological dynamics. As the climate change specter looms, this paper delves into the delicate interplay between changing climatic ...
Shiva S, Vundrala Sumedha Reddy, Vishnu Vijay Kumar, Sharan Chandran M, G Sivasubramanian   +4 more
doaj   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Lipopolysaccharide Purified from Salmonella typhi Sensitizes Human Red Blood Cells at Hemagglutinin concentration, leading to complete Hemolysis upon the addition of Jacalin- a lectin from Jackfruit

Exon
Lipopolysaccharides consist of a hydrophilic-polysaccharide region and a hydrophobic lipid compound known as lipid A. LPS has been reported to cause concentration-dependent agglutination of human RBCs. In this study, the HAP-Hot Aqueous-Phenol Extraction
Logesh Radhakrishnan, V Lavanya, Shazia Jamal, Neesar Ahmed   +3 more
doaj   +1 more source

Identification and characterisation of calcitonin receptor isoforms expressed in glioblastoma derived glioma stem and U‐87 MG cells

FEBS Open Bio, EarlyView.
Glioblastoma cells express calcitonin receptor variants (CT receptor isoforms) that may help them survive stress. Using qPCR, transcript‐specific long‐read nanopore sequencing, immunofluorescence co‐localisation and comparative sequence analysis, this study identifies a novel alternatively spliced CALCR transcript that encodes the CTb receptor isoform ...
Pragya Gupta, Sebastian GB Furness, Tahereh Gharbi, Ric De Paoli‐Iseppi, Shweta S. Joshi, Michael Clark, David L. Hare, Peter Wookey   +7 more
wiley   +1 more source

Prevalence of asymptomatic malaria amongst pregnant women in sub-divisional hospital (CMA) Muea, Southwest Region, Cameroon

Exon
Background Gestational malaria has been defined as the presence of Plasmodium spp. in maternal peripheral blood or the finding of the parasite in the placenta.
Evaris Paddy Nchianang Fonyuy, Eleonore Ngounou, Jemea Lyonga Ngoisah, Rex Mbah Tendong, Constantine Ndikum Njikem, Elisabeth Menkem Zeuko'o   +5 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source