Results 141 to 150 of about 838,049 (387)
Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte +13 more
wiley +1 more source
Nanotechnology and Biotechnology Against Multidrug-Resistant Pathogens: Promises and Challenges
ExonThe escalating threat of multidrug-resistant (MDR) pathogens necessitates innovative strategies that transcend conventional antibiotic paradigms. This review explores the transformative potential of integrating nanotechnology and biotechnology to address
Saad Ahmed
doaj +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Cultivation of Oyster Mushroom by using Two Different Substrates in Laboratory Condition
ExonMushrooms, a species of fungi, are cultivated worldwide using agricultural waste as a substrate due to their high lignin and cellulose content. This sustainable practice not only repurposes agricultural waste for mushroom production but also converts ...
Sneha Dwivedi +3 more
doaj +1 more source
Advanced Functional Materials, EarlyView.Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley +12 more
wiley +1 more source
In vitro Antibacterial Activity and Phytochemical Profiling of Selected Medicinal Plants
ExonThis study aimed to investigate the phytochemical composition and antimicrobial activity of five Indian medicinal plants: Azadirachta indica, Mangifera indica, Ocimum tenuiflorum, Solanum trilobatum, and Piper betle, which were selected for their ...
Mohamed Shafil S +5 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.Commercial vascular grafts are made from ePTFE, a highly hydrophobic, foreign material that fails at a high rate in small‐diameter applications. Plasma polymer nanoparticles (PPN) are a versatile material functionalisation tool, used here to present fibrillin‐1 fragment PF8 on the graft surface.
Bob S. L. Lee +9 more
wiley +1 more source
ExonThe golden shower tree, Cassia fistula, is a botanical symbol of persistence, providing aesthetic appeal and sophisticated ecological dynamics. As the climate change specter looms, this paper delves into the delicate interplay between changing climatic ...
Shiva S +4 more
doaj +1 more source
Advanced Healthcare Materials, EarlyView.We present a strategy to enhance magnetic hyperthermia therapy by modulating nanoparticle–cell interactions. Antibody‐functionalized magnetic nanoparticles targeting the low‐internalizing CCR9 receptor enable spatially controlled membrane anchoring, reducing aggregation and maximizing heat generation under alternating magnetic fields.
David Egea‐Benavente +5 more
wiley +1 more source