Results 171 to 180 of about 645,043 (338)

A database of orthologous exons in primates for comparative analysis of RNA-seq data [PDF]

, 2012
RNA-seq technology facilitates the study of gene expression at the level of individual exons and transcripts. Moreover, RNA-seq enables unbiased comparative analysis of expression levels across species.
Ran Blekhman
core   +1 more source

Exon-junction complex association with stalled ribosomes and slow translation-independent disassembly

Nature Communications
Exon junction complexes are deposited at exon-exon junctions during splicing. They are primarily known to activate non-sense mediated degradation of transcripts harbouring premature stop codons before the last intron.
Olivier Bensaude, Isabelle Barbosa, Lucia Morillo, Rivka Dikstein, Hervé Le Hir   +4 more
doaj   +1 more source

Type I C1 inhibitor deficiency with a small messenger RNA resulting from deletion of one exon. [PDF]

, 1989
Tadashi Ariga, Tomoko Igarashi, N Ramesh, Richard B. Parad, Marco Cicardi, Alvin E. Davis   +5 more
openalex   +1 more source

Exome Sequencing Reveals the Genetic Architecture of Non‐syndromic Orofacial Clefts and Identifies BOC as a Novel Causal Gene

Advanced Science, EarlyView.
Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial defects. Exome sequencing of 214 sporadic cases sheds new light on its genetic architecture and identifies many candidate pathogenic variants. Furthermore, functional studies establish BOC as a novel causal gene and reveal an unusual two‐locus model of inheritance via the epistatic
Qing He, Min Yu, Yuhua Jiao, Yizhu Xu, Xuqin Liang, Wenbin Huang, Linping Xu, Yuxia Hou, Zhanping Ren, Beile Lyu, Zhenwei Qian, Pengpeng Liu, Jing Zhou, Huimei Huang, Chunyan Yin, Huaxiang Zhao, Yi Ding   +16 more
wiley   +1 more source

The PreA4₆₉₅precursor protein of Alzheimer's disease A4 amyloid is encoded by 16 exons [PDF]

, 1989
H. G. Lemaire, J. Michael Salbaum, Gerd Multhaup, Jie Kang, Richard M. Bayney, Axel Unterbeck, Konrad Beyreuther, Benno Müller‐Hill   +7 more
openalex   +1 more source

The Length of the Downstream Exon and the Substitution of Specific Sequences Affect Pre-mRNA Splicing in Vitro

, 1988
Paul J. Furdon, Ryszard Kole
openalex   +3 more sources

IncRNA‐ZFAS1, an Emerging Gate‐Keeper in DNA Damage‐Dependent Transcriptional Regulation

Advanced Science, EarlyView.
LncZFAS1 plays a crucial role during DNA damage response in mammalian cells. Loss of lncZFAS1 results in deficient DNA lesion removal and reduced cell viability. Mechanistically, lncZFAS1 modulates RNAPII phosphorylation and transcription and thereby promotes both GG‐NER and TC‐NER upon UV damage.
Jiena Liu, Qing Lu, Zixuan Fan, Jiahui Lin, Nan He, Xin Zhang, Zhaoya Han, Tingting Zhu, Zhenzhen Wu, Yingying Xu, Yuming Wang   +10 more
wiley   +1 more source

Tissue and developmental regulation of fragile X mental retardation 1 exon 12 and 15 isoforms

Neurobiology of Disease, 2009
The pre-mRNA of the fragile X mental retardation 1 gene (FMR1) is subject to exon skipping and alternative splice site selection, which can generate up to 12 isoforms. The expression and function of these variants in vivo has not yet been fully explored.
Wen Xie, Natalia Dolzhanskaya, Giuseppe LaFauci, Carl Dobkin, Robert B. Denman   +4 more
doaj  

Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon. [PDF]

, 1984
Claude Gazin, S. Dupont de Dinechin, A Hampe, Jean‐Yves Masson, Patrick Martin, D. Stéhelin, Francis Galibert   +6 more
openalex   +1 more source

Integrating Dense Genotyping with High‐Throughput Phenotyping Empowers the Genetic Dissection of Berry Quality and Resilience Traits in Grapevine

Advanced Science, EarlyView.
Researchers develop advanced tools to study grapevine traits like berry quality and stress resilience. A 200K SNP array and high‐throughput phenotyping enable the identification of loci linked to berry shape, sugar content, acidity, and cold tolerance. Functional validation of genes such as NAC08 reveals roles in cold tolerance.
Yuyu Zhang, Yongjian Wang, Michael Henke, Pablo Carbonell‐Bejerano, Zemin Wang, Pierre‐François Bert, Yi Wang, Huayang Li, Junhua Kong, Peige Fan, Zhanwu Dai, Zhenchang Liang   +11 more
wiley   +1 more source