Results 271 to 280 of about 667,667 (355)

Detection of leukemia gene fusions on DNA-level through targeted Next-Generation Sequencing. [PDF]

PLoS One
Chen B, Gao Z, Chen L, Zhang H, Lin Y, Li J.   +5 more
europepmc   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Genome Mining and Structural Study of Cathelicidins Across Chiroptera Species. [PDF]

Biochem Res Int
López MR, González-Almécija B, Farrais-Solana F, Otazo-Pérez A, González-Acosta S, Asensio-Calavia P, Morales-delaNuez A, Pérez de la Lastra JM.   +7 more
europepmc   +1 more source

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function

Advanced Science, EarlyView.
Nestin localizes to the mitochondrial IMS through its MTS and the TOM20 import machinery. Within the mitochondria, Nestin interacts with Mic60 via its C‐terminal Tail3 domain. Loss of mitochondrial Nestin disrupts cristae architecture, leading to mitochondrial swelling, bioenergetic dysfunction, and ultimately the senescence of hMSCs.
Hainan Chen, Jinsi Chen, Li Huang, Xingqiang Lai, Kai Xia, Qiying Lu, Bingbing Xie, Yinong Huang, Yuan Qiu, Tao Wang, Jianqi Feng, Yuanjun Guan, Siyao Che, Jiancheng Wang, Andy Peng Xiang   +14 more
wiley   +1 more source

Conserved Calcineurin A splice variants regulate both constitutive and experience-dependent behaviors through tissue-specific signaling. [PDF]

PLoS Genet
Rudgalvyte M, Glauser DA.
europepmc   +1 more source

The Exon Theory of Genes

Cold Spring Harbor Symposia on Quantitative Biology, 1987
openaire   +2 more sources

Morphine Tolerance Gated through EZH2‐Mediated Suppression of Trpc5 in Spinal GABAergic Interneurons in Male Mice

Advanced Science, EarlyView.
Chronic morphine suppresses Trpc5 in spinal GABAergic interneurons via EZH2‐mediated histone modification, reducing Ca2+ influx and GABA release. TRPC5 activation enhances morphine analgesia, while EZH2 inhibition restores efficacy and reverses tolerance.
Li Wan, Mengyao Zhang, Haiyue Guo, Yan Xu, Chenjie Xu, Fan Hu, Yinbing Pan, Xian Wang, Wentao Liu, Chun‐Yi Jiang   +9 more
wiley   +1 more source

Defective GNAS imprinting due to splice site variants in pseudohypoparathyroidism type 1B. [PDF]

JCI Insight
Iwasaki Y, Reyes M, Molin A, Muurinen M, Kottler ML, Bastepe M, Jüppner H.   +6 more
europepmc   +1 more source

The maize transposable Ds1 element is alternatively spliced from exon sequences.

, 1991
Susan R. Wessler
openalex   +1 more source

Hepatic KLF9 Deficiency Inhibits Dehydroepiandrosterone (DHEA)‐Induced Polycystic Ovary Syndrome via Liver‐Ovary Axis

Advanced Science, EarlyView.
The study shows that liver is a previously unrecognized extraovarian organ that plays a key role about androgen homeostasis in the development of DHEA‐induced PCOS. DHEA is the most common precursor of active androgen, such as DHT, and KLF9 is required for the conversion of DHEA to DHT and hepatic KLF9 might be a potential therapeutic target for PCOS ...
Jianli Song, Zhaoqing Guan, Guiyi Ji, Jing Wang, Xiurui Yan, Yujie Zhang, Yinliang Zhang, Chunfang Ha, Rong Hu, Yongsheng Chang, Yaolin Zhang, Heng Fan   +11 more
wiley   +1 more source