Results 281 to 290 of about 396,684 (294)
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Influence of Exon Duplication on Intron and Exon Phase Distribution
Journal of Molecular Evolution, 1998Nonrandomness in the intron and exon phase distributions in a sample of 305 human genes has been found and analyzed. It was shown that exon duplications had a significant effect on the exon phase nonrandomness. All of the nonrandomness is probably due to both the processes of exon duplication and shuffling.
Eugeni Grigor'ev +4 more
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Nature Reviews Genetics, 2019
A study in Cell identifies a mechanism by which exon splicing can increase gene expression through the activation of weak upstream promoters.
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A study in Cell identifies a mechanism by which exon splicing can increase gene expression through the activation of weak upstream promoters.
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Isolation of Exons from Cloned DNA by Exon Trapping
Current Protocols in Human Genetics, 1994AbstractExon trapping is an RNA polymerase chain reaction (PCR) method to clone expressed sequences or exons directly from mammalian genomic DNA. The basic protocol in this unit describes the method for trapping internal exons from cosmid clones and the second basic protocol describes trapping of 3 terminal exons.
Paul C. Watkins +2 more
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The universe of exons revisited [PDF]
, 2003 We study the distribution of exons in eukaryotic genes to determine whether one can detect the reuse of exon sequences and to use the frequency of such reuse to estimate how many ancestral exon sequences there might have been. We use two databases of exons.
Serge Saxonov, Walter Gilbert
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Exons and the evolution of proteins
Trends in Biochemical Sciences, 1983Publisher Summary This chapter discusses exons and evolution of proteins. The splitting of most eukaryotic structural genes into coding sequences (exons) and noncoding sequences (introns) is widely interpreted in terms of evolutionary processes concerned with the gene products.
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Exon–exon junction – what's your function?
Trends in Cell Biology, 2001The expression of aberrant proteins can have disastrous consequences for a cell. Quality-control mechanisms that survey newly synthesized mRNAs are therefore essential to cellular well being. Unspliced pre-mRNAs are retained in the nucleus because they fail to associate with the appropriate export factors.
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The ribosome as an exon detector
Biosystems, 1996We present an analysis where different regions of small subunit rRNA are tested for their capacity to discriminate between coding and non-coding regions. We find that the 530 loop is one of the best sequences to be used in an algorithm for detecting exonic sites.
Jaime Lagúnez-Otero, Luis Mendoza
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Current Opinion in Structural Biology, 1994
Abstract Analysis of the exon-intron structures of genes, and a survey of the evolutionary distribution of mosaic proteins suggest that modularization of protein domains by intron insertions and their dispersal through exon-shuffling become significant only in higher eukaryotes.
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Abstract Analysis of the exon-intron structures of genes, and a survey of the evolutionary distribution of mosaic proteins suggest that modularization of protein domains by intron insertions and their dispersal through exon-shuffling become significant only in higher eukaryotes.
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Skipping of multiple CFTR exons is not a result of single exon omissions
Human Genetics, 1994The omission of complete exons in a proportion of mature transcripts has been shown for a variety of genes. In the case of the cystic fibrosis transmembrane conductance regulator gene, this phenomenon has previously been observed for exons 4, 9 and 12.
Jochen Reiss +3 more
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Science, 1999
Retrotransposons are mobile elements that move through the genome by reverse transcription of their RNA template. In his Perspective, Tom Eickbush discusses new findings reported in this issue by [Moran and colleagues][1] that suggest that the insertion of retrotransposable elements in the genome can be beneficial rather than deleterious as previously ...
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Retrotransposons are mobile elements that move through the genome by reverse transcription of their RNA template. In his Perspective, Tom Eickbush discusses new findings reported in this issue by [Moran and colleagues][1] that suggest that the insertion of retrotransposable elements in the genome can be beneficial rather than deleterious as previously ...
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