Results 21 to 30 of about 673,928 (346)

Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs

Frontiers in Genetics, 2014
To date, the main criterion by which long ncRNAs (lncRNAs) are discriminated from mRNAs is based on the capacity of the transcripts to encode a protein. However, it becomes important to identify non-ORF-based sequence characteristics that can be used to ...
Damien eUlveling, Marcel E Dinger, Claire eFrancastel, Florent eHubé   +3 more
doaj   +1 more source

Characterization of Global DNA Methylation in Different Gene Regions Reveals Candidate Biomarkers in Pigs with High and Low Levels of Boar Taint

Veterinary Sciences, 2020
DNA methylation of different gene components, including different exons and introns, or different lengths of exons and introns is associated with differences in gene expression.
Xiao Wang, Haja N. Kadarmideen
doaj   +1 more source

The lack of the Celf2a splicing factor converts a Duchenne genotype into a Becker phenotype [PDF]

, 2016
Substitutions, deletions and duplications in the dystrophin gene lead to either the severe Duchenne muscular dystrophy (DMD) or mild Becker muscular dystrophy depending on whether out-of-frame or in-frame transcripts are produced.
BOZZONI, Irene, Briganti, F, LEGNINI, IVANO, MARTONE, Julie, MORLANDO, MARIANGELA, Picillo, E, Politano, L, STHANDIER, Olga Elena   +7 more
core   +2 more sources

Frequencies of the MEFV Gene Mutations in Azerbaijan

Balkan Journal of Medical Genetics, 2022
The MEFV (familial Mediterranean fever gene) researches were performed in the population of the Republic of Azerbaijan in 2016–2021. Seven mutations of the MEFV gene were identified in heterozygous, homozygous and compound homozygous conditions: R761H ...
Huseynova LS, Mammadova SN, Aliyeva KAA
doaj   +1 more source

Phylogeny of Miliusa (Magnoliales: Annonaceae: Malmeoideae: Miliuseae), with descriptions of two new species from Malesia [PDF]

, 2013
The molecular phylogeny of Miliusa (Annonaceae) is reconstructed, with 27 (of ca. 50) species included, using a combination of seven plastid markers (rbcL exon, trnL intron, trnL-F spacer, matK exon, ndhF exon, psbA-trnH spacer, and ycf1 exon ...
Chaowasku, Tanawat, Keßler, Paul J. A.
core   +2 more sources

Scrambled exons

Cell, 1991
Using a sensitive assay for RNA expression, we identified several abnormally spliced transcripts in which exons from a candidate tumor suppressor gene (DCC) were scrambled during the splicing process in vivo. Cloning and sequencing of PCR-amplified segments of the abnormally spliced transcripts showed that exons were joined accurately at consensus ...
J M, Nigro, K R, Cho, E R, Fearon, S E, Kern, J M, Ruppert, J D, Oliner, K W, Kinzler, B, Vogelstein   +7 more
openaire   +2 more sources

Noncoder : a web interface for exon array-based detection of long non-coding RNAs [PDF]

, 2012
Due to recent technical developments, a high number of long non-coding RNAs (lncRNAs) have been discovered in mammals. Although it has been shown that lncRNAs are regulated differently among tissues and disease statuses, functions of these transcripts ...
Braun, Thomas, Gellert, Pascal, Ponomareva, Yuliya, Uchida, Shizuka   +3 more
core   +1 more source

Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3 [PDF]

, 2009
Background: Alternative splicing (AS) of maturing mRNA can generate structurally and functionally distinct transcripts from the same gene. Recent bioinformatic analyses of available genome databases inferred a positive correlation between intron length ...
A Marchler-Bauer, A Mortazavi, A Nekrutenko, A Rambaut, A Resch, AA Patel, AB Carvalho, AE Vinogradov, AG Clark, AM McGuire, AN Ladd, AR Hatton, AS Chang, AV Alekseyenko, AV Philips, B Budagyan, B Modrek, B Modrek, B Prud'homme, BR Graveley, BR Graveley, BR Graveley, C Lee, C Notredame, CI Castillo-Davis, CL Fitzpatrick, CS Thummel, D Babushok, D Baek, D Gatfield, D Monroe, D Ortíz-Barrientos, DA Petrov, DA Petrov, DG Gilbert, DI Nurminsky, DJ Kenan, DL Black, DL Swofford, E Betran, E Kim, E Kim, E Wagner, EA Glazov, F-C Chen, FA Kondrashov, G Ast, G Lev-Maor, G Marais, GD Schuler, H Itoh, IA Swinburne, International Human Genome Sequencing Consortium, J Delaunay, J Felsenstein, J Rozas, JM Burnette, JM Comeron, JM Johnson, K Tamura, KL Fox-Walsh, KM Neugebauer, LF Lareau, M Clamp, M Guo, M Labrador, M Lynch, M Roy, M Talerico, MA Noor, MD Adams, MD Adams, MF Wilkinson, Mohamed AF Noor, MT Levine, Nikolai P Kandul, NJ Proudfoot, NM Kopelman, P Haddrill, PA Sharp, PJ Good, PM O'Grady, Q Pan, R Sorek, R Sorek, R Sorek, R Sorek, R Sorek, S Karlin, S Misra, S Richards, S-T Chen, SF Altschul, SM Berget, TE Royce, V Stolc, W Wang, WG Hill, Y Xing, Y Xing, Z Kan   +100 more
core   +5 more sources

In Vivo Recognition of a Vertebrate Mini-Exon as an Exon-Intron-Exon Unit

Molecular and Cellular Biology, 1993
Very small vertebrate exons are problematic for RNA splicing because of the proximity of their 3' and 5' splice sites. In this study, we investigated the recognition of a constitutive 7-nucleotide mini-exon from the troponin I gene that resides quite close to the adjacent upstream exon.
D A, Sterner, S M, Berget
openaire   +3 more sources

Conservation of the Exon-Intron Structure of Long Intergenic Non-Coding RNA Genes in Eutherian Mammals

Life, 2016
The abundance of mammalian long intergenic non-coding RNA (lincRNA) genes is high, yet their functions remain largely unknown. One possible way to study this important question is to use large-scale comparisons of various characteristics of lincRNA with ...
Diana Chernikova, David Managadze, Galina V. Glazko, Wojciech Makalowski, Igor B. Rogozin   +4 more
doaj   +1 more source