Results 21 to 30 of about 395,522 (295)
Exon Skipping Is Correlated with Exon Circularization
Journal of Molecular Biology, 2015 Circular RNAs are found in a wide range of organisms and it has been proposed that they perform disparate functions. However, how RNA circularization is connected to alternative splicing remains largely unexplored. Here, we stimulated primary human endothelial cells with tumor necrosis factor α or tumor growth factor β, purified RNA, generated >2.4 ...
Peter R. Cook +4 more
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Periodicity of DNA in exons [PDF]
BMC Molecular Biology, 2004 Abstract Background The periodic pattern of DNA in exons is a known phenomenon. It was suggested that one of the initial causes of periodicity could be the universal (RNY) n pattern (R = A or G, Y = C or U, N = any base) of ancient RNA.
Anatoly Ruvinsky +3 more
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Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs
Frontiers in Genetics, 2014 To date, the main criterion by which long ncRNAs (lncRNAs) are discriminated from mRNAs is based on the capacity of the transcripts to encode a protein. However, it becomes important to identify non-ORF-based sequence characteristics that can be used to ...
Damien eUlveling +3 more
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ExPrimer: to design primers from exon--exon junctions [PDF]
Bioinformatics, 2005 ExPrimer is a web-based computer program to design primers mainly from a specified exon-exon junction (E-E-jn) of a gene of interest. The tool suggests the optimum primer-pair(s) of which the right (reverse) primer represents a particular E-E-jn of the mRNA. The 'product length' decides the location of the left primer.
Kshitish K. Acharya +1 more
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Life, 2016 The abundance of mammalian long intergenic non-coding RNA (lincRNA) genes is high, yet their functions remain largely unknown. One possible way to study this important question is to use large-scale comparisons of various characteristics of lincRNA with ...
Diana Chernikova +4 more
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Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2–8) in Normal and Cancerous Breast and Prostate Cells [PDF]
International Journal of Molecular Sciences, 2016 Nearly 20 different transcripts of the human androgen receptor (AR) are reported with two currently listed as Refseq isoforms in the NCBI database. Isoform 1 encodes wild-type AR (type 1 AR) and isoform 2 encodes the variant AR45 (type 2 AR). Both variants contain eight exons: they share common exons 2–8 but differ in exon 1 with the canonical exon 1 ...
Dong Hu +4 more
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Correlation of KIT and PDGFRA mutation status with clinicopathologic features in primary and recurrent or metastatic gastrointestinal stromal tumors [PDF]
Zhenduanxue lilun yu shijian, 2021 Objective: To investigate the correlation of KIT and PDGFRA mutation status with immunohistochemistry (IHC) and clinicopathological features in the primary, recurren tor metastatic gastrointestinal stromal tumors (GIST).
GU Yijin, LI Anqi, DONG Lei, XU Haimin, SHEN Xia, XIE Jialing, YUAN Fei, WANG Chaofu
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Exon Inclusion Is Dependent on Predictable Exonic Splicing Enhancers [PDF]
Molecular and Cellular Biology, 2005 We have previously formulated a list of approximately 2,000 RNA octamers as putative exonic splicing enhancers (PESEs) based on a statistical comparison of human exonic and nonexonic sequences (X. H. Zhang and L. A. Chasin, Genes Dev. 18:1241-1250, 2004).
Lawrence A. Chasin +4 more
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Veterinary Sciences, 2020 DNA methylation of different gene components, including different exons and introns, or different lengths of exons and introns is associated with differences in gene expression.
Xiao Wang, Haja N. Kadarmideen
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In Vivo Recognition of a Vertebrate Mini-Exon as an Exon-Intron-Exon Unit
Molecular and Cellular Biology, 1993 Very small vertebrate exons are problematic for RNA splicing because of the proximity of their 3' and 5' splice sites. In this study, we investigated the recognition of a constitutive 7-nucleotide mini-exon from the troponin I gene that resides quite close to the adjacent upstream exon.
D A Sterner, Susan M. Berget
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