Gene Architecture Facilitates Intron-Mediated Enhancement of Transcription
Frontiers in Molecular Biosciences, 2021 Introns impact several vital aspects of eukaryotic organisms like proteomic plasticity, genomic stability, stress response and gene expression. A role for introns in the regulation of gene expression at the level of transcription has been known for more ...
Katherine Dwyer +3 more
doaj +1 more source
Molecular determinants of drug-specific sensitivity for epidermal growth factor receptor (EGFR) exon 19 and 20 mutants in non-small cell lung cancer. [PDF]
, 2015 We hypothesized that aberrations activating epidermal growth factor receptor (EGFR) via dimerization would be more sensitive to anti-dimerization agents (e.g., cetuximab).
Bazhenova, Lyudmila +6 more
core +3 more sources
The lack of the Celf2a splicing factor converts a Duchenne genotype into a Becker phenotype [PDF]
, 2016 Substitutions, deletions and duplications in the dystrophin gene lead to either the severe Duchenne muscular dystrophy (DMD) or mild Becker muscular dystrophy depending on whether out-of-frame or in-frame transcripts are produced.
BOZZONI, Irene +7 more
core +2 more sources
Identification of a dinucleotide signature that discriminates coding from non-coding long RNAs
Frontiers in Genetics, 2014 To date, the main criterion by which long ncRNAs (lncRNAs) are discriminated from mRNAs is based on the capacity of the transcripts to encode a protein. However, it becomes important to identify non-ORF-based sequence characteristics that can be used to ...
Damien eUlveling +3 more
doaj +1 more source
ExPrimer: to design primers from exon--exon junctions [PDF]
Bioinformatics, 2005 ExPrimer is a web-based computer program to design primers mainly from a specified exon-exon junction (E-E-jn) of a gene of interest. The tool suggests the optimum primer-pair(s) of which the right (reverse) primer represents a particular E-E-jn of the mRNA. The 'product length' decides the location of the left primer.
Kshitish K. Acharya +1 more
openaire +3 more sources
A Bidirectional LSTM-RNN and GRU Method to Exon Prediction Using Splice-Site Mapping
Applied Sciences, 2022 Deep Learning techniques (DL) significantly improved the accuracy of predictions and classifications of deoxyribonucleic acid (DNA). On the other hand, identifying and predicting splice sites in eukaryotes is difficult due to many erroneous discoveries ...
Peren Jerfi CANATALAY, Osman Nuri Ucan
doaj +1 more source
Novel Nine-Exon AR Transcripts (Exon 1/Exon 1b/Exons 2–8) in Normal and Cancerous Breast and Prostate Cells [PDF]
International Journal of Molecular Sciences, 2016 Nearly 20 different transcripts of the human androgen receptor (AR) are reported with two currently listed as Refseq isoforms in the NCBI database. Isoform 1 encodes wild-type AR (type 1 AR) and isoform 2 encodes the variant AR45 (type 2 AR). Both variants contain eight exons: they share common exons 2–8 but differ in exon 1 with the canonical exon 1 ...
Dong Hu +4 more
openaire +2 more sources
Noncoder : a web interface for exon array-based detection of long non-coding RNAs [PDF]
, 2012 Due to recent technical developments, a high number of long non-coding RNAs (lncRNAs) have been discovered in mammals. Although it has been shown that lncRNAs are regulated differently among tissues and disease statuses, functions of these transcripts ...
Braun, Thomas +3 more
core +1 more source
From Order to Chaos: Publication, Synthesis and the Dissemination of Data in a Digital Age
Internet Archaeology, 1999 In the past, the provision of authoritative, interpretative, syntheses is what archaeologists sought through publication. Now the first real challenge of the digital age has been to balance this trend and in contrast to archaeological practice over the ...
Vince Gaffney , Sally Exon
doaj +1 more source
PMP22 exon 4 deletion causes ER retention of PMP22 and a gain-of-function allele in CMT1E [PDF]
, 2017 OBJECTIVE: To determine whether predicted fork stalling and template switching (FoSTeS) during mitosis deletes exon 4 in peripheral myelin protein 22 KD (PMP22) and causes gain‐of‐function mutation associated with peripheral neuropathy in a family with ...
Bai, Yunhong +8 more
core +2 more sources