Results 51 to 60 of about 645,043 (338)

Correlation of KIT and PDGFRA mutation status with clinicopathologic features in primary and recurrent or metastatic gastrointestinal stromal tumors [PDF]

Zhenduanxue lilun yu shijian, 2021
Objective: To investigate the correlation of KIT and PDGFRA mutation status with immunohistochemistry (IHC) and clinicopathological features in the primary, recurren tor metastatic gastrointestinal stromal tumors (GIST).
GU Yijin, LI Anqi, DONG Lei, XU Haimin, SHEN Xia, XIE Jialing, YUAN Fei, WANG Chaofu
doaj   +1 more source

Scrambled exons

Cell, 1991
Using a sensitive assay for RNA expression, we identified several abnormally spliced transcripts in which exons from a candidate tumor suppressor gene (DCC) were scrambled during the splicing process in vivo. Cloning and sequencing of PCR-amplified segments of the abnormally spliced transcripts showed that exons were joined accurately at consensus ...
J M, Nigro, K R, Cho, E R, Fearon, S E, Kern, J M, Ruppert, J D, Oliner, K W, Kinzler, B, Vogelstein   +7 more
openaire   +2 more sources

Complex exon-intron marking by histone modifications is not determined solely by nucleosome distribution [PDF]

, 2010
It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons (“exon-intron marking”), linking chromatin structure and function to co-transcriptional ...
A Barski, A Tyagi, AJ Bannister, Alexander W. Bruce, Anton Wutz, AW Bruce, AW Bruce, B Langmead, B Li, BB Lozzio, BE Bernstein, Christoph M. Koch, CK Lee, CM Koch, Cordelia Langford, David Vetrie, E Allemand, E Batsche, E Birney, EC Forsberg, G Felsenfeld, G Hon, G Nogues, H Tilgner, Ian Dunham, IE Schor, Jackie Bye, JW Larrick, Keith James, Kelly Chiang, KJ Howe, M Allo, M de la Mata, M Yonaha, MC Keogh, MJ Carrozza, N Spies, NA Watkins, ND Heintzman, ND Robson-Dixon, Nicholas A. Watkins, Nicola S. Foad, Nicolas Bonhoure, NJ Park, P Dhami, P Kolasinska-Zwierz, Pawandeep Dhami, Peter Ellis, Peter Saffrey, PG Giresi, PL Nagy, R Andersson, R Landick, RF Luco, RJ Sims, RJ Sims, RK Auerbach, Robert M. Andrews, S Cuddapah, S Nahkuri, S Schwartz, S Schwartz, Shane C. Dillon, T Jenuwein, Willem H. Ouwehand, Y Mito, Z Wang   +66 more
core   +4 more sources

Functional Characterization of Argininosuccinate Lyase Gene Variants by Mini-Gene Splicing Assay

Frontiers in Genetics, 2019
ObjectiveArgininosuccinate lyase (ASL) gene mutations account for argininosuccinic aciduria (ASA). This study aimed to design a minigene construct of ASL gene in order to investigate the impact of variants on splicing.MethodsThe peripheral blood samples ...
Yanyun Wang, Yun Sun, Ming Liu, Xiaojuan Zhang, Tao Jiang, Tao Jiang   +5 more
doaj   +1 more source

Altered splicing of the BIN1 muscle-specific exon in humans and dogs with highly progressive centronuclear myopathy [PDF]

, 2013
Amphiphysin 2, encoded by BIN1, is a key factor for membrane sensing and remodelling in different cell types. Homozygous BIN1 mutations in ubiquitously expressed exons are associated with autosomal recessive centronuclear myopathy (CNM), a mildly ...
A Buj-Bello, A Lujan Feliu-Pascual, A Razzaq, A Tjondrokoesoemo, A Toussaint, AC Durieux, AH Beggs, AJ Muller, Anne Toussaint, AS Nicot, AY Mejaddam, B Qualmann, B Sinha, Belinda Cowling, BJ Peter, BS Cowling, C Fugier, C Kojima, C Spiegelhalter, CJ McMillan, CR Pierson, D Bansal, D Grabs, D Sakamuro, DJ Owen, E Lee, G Di Paolo, G Ren, G. Diane Shelton, Gregory A. Cox, H Jungbluth, Ivana Prokic, J Bohm, J Laporte, J Weis, JJ Dowling, Joachim Weis, Jocelyn Laporte, Johann Böhm, KC Chang, KG Claeys, L Klinge, Laurent Tiret, M Bitoun, M Maurer, M Pele, Marie Maurer, MH Butler, Nasim Vasli, NB Romero, NC Mao, R Wechsler-Reya, RJ Wechsler-Reya, S Pant, SE Davies, T Itoh, Thomas James Anderson, Ulrike Schara, Wolfram Kress   +58 more
core   +11 more sources

New Frontiers in Scientific Drilling of the Indian Ocean [PDF]

Scientific Drilling, 2012
No abstract available.
Mike Coffin, S. Rajan, Dhananjai Pandey, Stephen J. Gallagher, Neville Exon, Ken Takai   +5 more
doaj   +2 more sources

The CUGBP2 splicing factor regulates an ensemble of branchpoints from perimeter binding sites with implications for autoregulation [PDF]

, 2009
Alternative pre-mRNA splicing adjusts the transcriptional output of the genome by generating related mRNAs from a single primary transcript, thereby expanding protein diversity.
Dembowski, JA, Grabowski, PJ
core   +5 more sources

Genetic variability at exon 2 of inhibin alpha locus in malabari goats of kerala [PDF]

Journal of Veterinary and Animal Sciences, 2020
The present study included 207 Malabari goats from six centers viz., University Goat and Sheep Farm, Mannuthy and 5 field centres of the ICAR-All India Coordinated Research Project on Goat Improvement (Malabari).
Haritha B. Pillai, R. Thirupathy Venkatachalapathy, T.V. Aravindakshan, Jamuna Valsalan, K. Raji   +4 more
doaj  

Identification of an osteocalcin isoform in fish with a large acidic prodomain [PDF]

, 2014
Osteocalcin is a small, secreted bone protein whose gene consists of four exons. In the course of analyzing the structure of fish osteocalcin genes, we recently found that the spotted green pufferfish has two possible exon 2 structures, one of 15 bp and ...
Amores, Boskey, Chomczynski, Christensen, Crooks, Ducy, Engelke, Frazão, Gorski, Gundberg, Hauschka, Hauschka, He, Hosoda, Hunter, Huq, Jaillon, Kumar, Laizé, Nakayama, Nielsen, Nishimoto, Notredame, Patthy, Poser, Price, Sommer, Stothard, Taylor, Thompson, Woods   +30 more
core   +1 more source

Synthetic polypeptides using a biologic as a reference medicinal product – the European landscape of regulatory approvals

Frontiers in Medicine
Recent advances in synthetic drug manufacturing have introduced a new dynamic to the European regulatory system, with chemically synthesized polypeptide products using biological originator products as their reference medicine.
Kevin Klein, Jens Heisterberg, Pieter Stolk   +2 more
doaj   +1 more source