Results 51 to 60 of about 394,574 (252)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Urease: Kinetic and Thermodynamic Mechanisms and Their Diverse Applications
ExonMicrobial urease (amidohydrolase, EC 3.5.1.5) is a metalloenzyme of significant biological and ecological importance, widely distributed among various microorganisms including bacteria, fungi, and archaea.
Amiya Ojha +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
ExonBackground: Hepatitis B virus infection is one of the most common sexually transmitted diseases. It causes severe damage to the liver there by obstructing its functioning. However, some communities are not aware of its severity. Objective: To assess
Jemea Lyonga Ngoisah +9 more
doaj +1 more source
In Vivo Recognition of a Vertebrate Mini-Exon as an Exon-Intron-Exon Unit
Molecular and Cellular Biology, 1993 Very small vertebrate exons are problematic for RNA splicing because of the proximity of their 3' and 5' splice sites. In this study, we investigated the recognition of a constitutive 7-nucleotide mini-exon from the troponin I gene that resides quite close to the adjacent upstream exon.
D A, Sterner, S M, Berget
openaire +3 more sources
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
ExonUrease is an enzyme that plays a significant role in the pathogenesis of Helicobacter pylori responsible for numerous health issues, among which chronic gastritis, peptic ulcer disease, gastric neoplasia and even stomach cancer.
Doriane Perlise Lienou +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Extraction and Purification of Melanin from Different Sources and Tissues
ExonMelanins are phenolic biopolymers synthesized by most of the living organism mainly for photoprotection or surviving in harsh conditions. Melanin is localized in different areas or complexed with different other biomolecules when observed from animals to
Noble K Kurian
doaj +1 more source
Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276
FEBS Open Bio, EarlyView.Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig +7 more
wiley +1 more source