Results 161 to 170 of about 240,839 (324)
Topological Entropy of DNA Sequences [PDF]
arXiv, 2011 Topological entropy has been one of the most difficult to implement of all the entropy-theoretic notions. This is primarily due to finite sample effects and high-dimensionality problems. In particular, topological entropy has been implemented in previous literature to conclude that entropy of exons is higher than of introns, thus implying that exons ...
arxiv
Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing
Small, EarlyView.The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa +4 more
wiley +1 more source
CTCF Degradation Causes Increased Usage of Upstream Exons in Mouse Embryonic Stem Cells [PDF]
arXiv, 2018 Transcriptional repressor CTCF is an important regulator of chromatin 3D structure, facilitating the formation of topologically associating domains (TADs). However, its direct effects on gene regulation is less well understood. Here, we utilize previously published ChIP-seq and RNA-seq data to investigate the effects of CTCF on alternative splicing of ...
arxiv
An Empirical Exploration of Skip Connections for Sequential Tagging [PDF]
arXiv, 2016 In this paper, we empirically explore the effects of various kinds of skip connections in stacked bidirectional LSTMs for sequential tagging. We investigate three kinds of skip connections connecting to LSTM cells: (a) skip connections to the gates, (b) skip connections to the internal states and (c) skip connections to the cell outputs.
arxiv
A short CIC-2 mRNA transcript is produced by exon skipping [PDF]
, 1996 S Chu
openalex +1 more source
Opportunities and Challenges of Population Pharmacogenomics
Annals of Human Genetics, EarlyView.ABSTRACT Pharmacological responses can vary significantly among patients from different ethnogeographic backgrounds. This variability can, at least in part, be attributed to population‐specific genetic patterns in genes involved in drug absorption, distribution, metabolism, and excretion, as well as in genes associated with drug‐induced toxicity ...
Yitian Zhou +3 more
wiley +1 more source
Information Analysis of DNA Sequences [PDF]
arXiv, 2010 The problem of differentiating the informational content of coding (exons) and non-coding (introns) regions of a DNA sequence is one of the central problems of genomics. The introns are estimated to be nearly 95% of the DNA and since they do not seem to participate in the process of transcription of amino-acids, they have been termed "junk DNA ...
arxiv
A nonsense mutation in the 3-hydroxy-3-methylglutaryl-CoA lyase gene produces exon skipping in two patients of different origin with 3-hydroxy-3-methylglutaryl-CoA lyase deficiency [PDF]
, 1997 Juan Pié +11 more
openalex +1 more source
exon skipping as a therapeutic strategy in dysferlinopathy
, 2018 Dysferlinopathie ist eine Muskeldystrophie, die sich in zwei Hauptphänotypen manifestiert: Gliedergürtelmuskeldystrophie Typ 2B type 2B (LGMD2B) oder Miyoshi Myopathie (MM). Sie wird durch Mutationen im Dysferlin-Gen verursacht. Dysferlin ist ein Membranprotein, das im Skeletmuskel exprimiert wird.
openaire +2 more sources
Andrology, EarlyView.Abstract Background Small RNAs interacting with PIWI (piRNAs) play a crucial role in regulating transposable elements and translation during spermatogenesis and are essential in male germ cell development. Disruptions in the piRNA pathway typically lead to severe spermatogenic defects and thus male infertility. The HENMT1 gene is a key player in piRNAs
Zeina Wehbe +17 more
wiley +1 more source