Results 221 to 230 of about 51,494 (318)

A TLR8 Variant Identified From Whole Exome Sequencing as a Sepsis‐Prone Mutation

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
Whole‐exome sequencing of sepsis patients identified a recurrent high‐impact TLR8 rs3764880 variant enriched in bacterial sepsis. Single‐cell transcriptomics localized elevated TLR8 expression to non‐classical monocytes, while bulk RNA‐seq and functional assays demonstrated enhanced IFN‐β responses following TLR8 stimulation.
Fahd Alhamdan, Stefano Gianoli, Xioahui Han, Sophia Koutsogiannaki   +3 more
wiley   +1 more source

Target choice and exon skipping regulate CRISPR-directed gene editing of NRF2 in head/neck and esophageal cancer cells. [PDF]

Mol Ther Oncol
Rivera-Torres N, Skelly LE, Rogowskyj JA, Aguilar G, Banas K, Bialk P, Kmiec EB.   +6 more
europepmc   +1 more source

Molecular mechanisms of sex determination in Lepidoptera: current status and perspectives

Insect Science, Volume 33, Issue 2, Page 599-617, April 2026.
The genetic basis of sex determination in Lepidoptera was discovered in 2014 in the silkworm Bombyx mori. In this model species, the W chromosome‐derived small piRNA called Fem piRNA downregulates the expression of a Z‐linked gene, Masculinizer (Masc), which leads to the default female‐specific splicing of the doublesex gene (dsxF) and thus to female ...
František Marec, Atsuo Yoshido, Arjen E. van′t Hof   +2 more
wiley   +1 more source

PPMO-based exon skipping therapy improves respiratory function in the <i>mdx</i> mouse model of Duchenne muscular dystrophy. [PDF]

Mol Ther Nucleic Acids
Biswas DD, Rodriguez MYH, El Haddad L, Hoffmann G, Copson E, Mayman S, Jose J, Lang S, Chen O, Dela Pena A, Levin E, Abdelbarr M, Slyne A, ElMallah MK.   +13 more
europepmc   +1 more source

Branchpoints as potential targets of exon-skipping therapies for genetic disorders. [PDF]

Mol Ther Nucleic Acids, 2023
Ohara H, Hosokawa M, Awaya T, Hagiwara A, Kurosawa R, Sako Y, Ogawa M, Ogasawara M, Noguchi S, Goto Y, Takahashi R, Nishino I, Hagiwara M.   +12 more
europepmc   +1 more source

Antisense oligonucleotide-mediated exon skipping strategies as the treatment for rare diseases

, 2020
Dunhui Li
openalex   +1 more source

Reliable Inference of Phylogenomic Relationship via Assembly‐Based Strategy Accommodating Raw Reads and Proteins

Molecular Ecology Resources, Volume 26, Issue 3, April 2026.
ABSTRACT Phylogenomics is a transformative approach in systematics, conservation biology, and biomedical research, enabling the inference of evolutionary relationships by leveraging hundreds to thousands of genes from genomic or transcriptomic data. However, acquiring high‐quality genomes and transcriptomes necessitates samples with intact DNA and RNA,
Yunlong Li, Xu Liu, Chong Chen, Jian‐Wen Qiu, Kevin M. Kocot, Jin Sun   +5 more
wiley   +1 more source

CRISPR-directed exon skipping; friend or foe (opportunity or warning sign)? [PDF]

Mol Ther Nucleic Acids
Banas KH, Kmiec EB.
europepmc   +1 more source

Widespread Prevalence of CD19 Exon 5-6 Skipping In Indian Pediatric B-cell Acute Lymphoblastic Leukemia Patients [PDF]

Devesh Srivastava, Anurag Gupta, Nishant Verma, Ashish Misra   +3 more
openalex   +1 more source

Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutation Testing Trends, Prevalence, and Outcomes in Metastatic, Non‐Squamous Non‐Small Cell Lung Cancer (Non‐SQ NSCLC) Patients in Queensland, Australia From 2014–2023

Thoracic Cancer, Volume 17, Issue 7, April 2026.
KRAS mutations remain the most prevalent oncogenic driver mutation seen in metastatic nonsquamous nonsmall cell lung cancer and a key target for further drug development. This study has highlighted the significant improvement seen in KRAS testing rates over time, with characteristics of Australian KRAS mutant patients corresponding with published ...
Navin Niranjan, Tracey Guan, Nitin Niranjan, Atefeh Taherian Fard, Danny R. Youlden, Robert Mason, Bryan A. Chan, Jasotha Sanmugarajah   +7 more
wiley   +1 more source