Results 221 to 230 of about 586,929 (366)

Neratinib Efficacy in Patients With EGFR Exon 18-Mutant Non-Small-Cell Lung Cancer: Findings From the SUMMIT Basket Trial

Jonathan W. Goldman, A. Martinez Bueno, Christophe Dooms, Komal Jhaveri, Maria J. de Miguel, Sarina A. Piha‐Paul, Nisha Unni, Aviad Zick, Amit Mahipal, Jennifer M. Suga, Charles Naltet, M. Antoñanzas, John Crown, Judith D. Bebchuk, Lisa D. Eli, Barbara Lowenthal, Devalingam Mahalingam   +16 more
openalex   +1 more source

Smohaze‐Upregulated RFWD3 Competes with TRIM24 to Stabilize TREX1 and Reduce Cytosolic dsDNA in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
The E3 ubiquitin ligase RFWD3 binds the exonuclease TREX1 and protects it from TRIM24‐mediated ubiquitination and degradation, leading to the eradication of intracellular dsDNA, inhibition of the cGAS‐STING pathway, and immunosuppressive microenvironment of lung cancer.
Xue‐Yan Shi, Yu‐Ke Shen, Meng‐Yao Lv, Yu Sun, Yong‐Fang Lin, Zheng Wang, Xiao‐Liang Jie, Zheng Liu, Yang‐Tong Liu, Yang‐Xin Fu, Zhenhua Ren, Gui‐Zhen Wang, Guang‐Biao Zhou   +12 more
wiley   +1 more source

Longer internal exons tend to have more tandem repeats and more frequently experience insertions and deletions. [PDF]

Life Sci Alliance
Homma K, Anbo H, Ota M, Fukuchi S.
europepmc   +1 more source

Exon [PDF]

, 2020
openaire   +1 more source

Integrated Exon and Intron Splicing Analysis Identifies Novel GAS5 and PVT1 Regulatory Junctions in Esophageal Adenocarcinoma [PDF]

John Mathew Manipadam
openalex   +1 more source

Treatment with Minicircle DNA Expressing a FGF23 Fragment in a Clinically relevant Mouse Model of X‐Linked Hypophosphatemic Rickets

Advanced Science, EarlyView.
The pathogenic role of PHEX isn't fully determined, and there is no radical cure for X‐linked hypophosphatemic rickets (XLHR). This study makes the first attempt to perform gene therapy using a minicircle DNA (MC‐DNA) vector expressing a fragment of FGF23 (amino acids 180‐251) in Phex‐T1349C mice and suggests MC‐DNA as a promisingly safe and effective ...
Huixiao Wu, Wanyi Zhao, Xinyu Chen, Yanzhou Wang, Shuoshuo Wei, Bo Xiang, Yingzhou Shi, Zongyue Li, Yangyang Yao, Jin Xie, Renyuan Qiu, Meng Shu, Shuo Xu, Ping Chen, Zhiying Chen, Yingjie Wu, Weibo Xia, Ling Gao, Yongfeng Song, Jiajun Zhao, Chao Xu   +20 more
wiley   +1 more source

A Novel <i>VPS13A</i> Deletion in <i>VPS13A</i> Disease (Chorea-Acanthocytosis): A Case Report with Brief Literature Summary. [PDF]

Int J Mol Sci
Perrone B, Mosca V, Pecoraro M, Ruffo P, Giudice ED, Leon A, Maino M, La Bella V, Spataro R, Conforti FL.   +9 more
europepmc   +1 more source

Genomic structure of DNA encoding the lymphocyte homing receptor CD44 reveals at least 12 alternatively spliced exons.

Proceedings of the National Academy of Sciences of the United States of America, 1992
G. Screaton, M. Bell, D. Jackson, F. Cornélis, U. Gerth, J. Bell   +5 more
semanticscholar   +1 more source

CircLRBA Promotes Epithelial‐Mesenchymal Transition, Immune Evasion, Chemoimmunotherapy Resistance and Metastasis Through Stabilizing Twist1

Advanced Science, EarlyView.
CircLRBA is highly expressed in breast cancer (BC) and associated with poor overall survival. Zeb1 mediated circLRBA facilitates BC cell proliferation, invasion, docetaxel (DTX) resistance and inhibits the infiltration of CD8+ T cell. CircLRBA could combine with SPOP to suppress the Twist1 ubiquitination degradation and enhances PD‐L1 transcription ...
Xiaosong Wang, Xin Yang, Lei Xing, Hang Chen, Fuming Xie, Bin Wang, Bowen Shi, Yan Yang, Junxia Chen   +8 more
wiley   +1 more source

Monomeric and Oligomeric Decorsins of the Asian Medicinal Leech <i>Hirudinaria manillensis</i>. [PDF]

Int J Mol Sci
Tolksdorf C, Wolf R, Rauch BH, Jedlitschky G, Müller C.   +4 more
europepmc   +1 more source