Results 281 to 290 of about 586,929 (366)

MSC Membrane‐Coated circPROSC‐siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification

Advanced Science, EarlyView.
CircPROSC promotes craniosynostosis by sponging miR‐6815‐5p, thereby activating WNT3A/β‐catenin signaling and enhancing RUNX2‐mediated osteogenesis. Targeted silencing of circPROSC with MSC membrane–coated siRNA nanoparticles (MM@Lipo/si‐circPROSC) delivered postnatally into cranial sutures attenuates premature suture closure in Twist1+/– mice ...
Zhenkun Weng, Xiu Chen, Jin Xu, Qing Yan, Jian Jiao, Qian Liu, Aihua Gu   +6 more
wiley   +1 more source

Designated primers targeted canine <i>TP53</i> gene hotspot regions. [PDF]

Open Vet J
Ali FA, Al-Zebeeby A.
europepmc   +1 more source

The LDL receptor gene: a mosaic of exons shared with different proteins.

Science, 1985
T. Südhof, J. Goldstein, Michael S. Brown, D. Russell   +3 more
semanticscholar   +1 more source

ACSL5 Regulates Glucose Metabolism and Chemotherapy Sensitivity in Colorectal Cancer Cells under Glutamine Deficiency

Advanced Science, EarlyView.
Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian, Qiaoxia Zhang, Xuedan Sun, Rick Francis Thorne, Zeyuan Shi, Qiang Ji, Zhangran Sun, Yuanxiang Lu, Qun Zhao, Xianjun Yu, Wanglai Hu, Mian Wu   +11 more
wiley   +1 more source

PTBP1 depletion in mature astrocytes reveals distinct splicing alterations without neuronal features. [PDF]

Elife
Zhang M, Kubota N, Nikom D, Arient A, Zheng S.   +4 more
europepmc   +1 more source

Changes in exon-intron structure during vertebrate evolution affect the splicing pattern of exons.

Genome Research, 2012
S. Gelfman, D. Burstein, Osnat Penn, A. Savchenko, Maayan Amit, Schraga Schwartz, T. Pupko, G. Ast   +7 more
semanticscholar   +1 more source

Exon [PDF]

, 2018
openaire   +2 more sources

Regulation of Alternative RNA Splicing by Exon Definition and Exon Sequences in Viral and Mammalian Gene Expression

, 2004
Zhi‐Ming Zheng
openalex   +2 more sources

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Conservation and Remodeling of Alternative Splicing Landscapes in the Evolution of <i>Panax</i>. [PDF]

Plants (Basel)
Zhao J, Meng X, Di P, Rong J, Xun H, Zheng S, Li J, Zhang J, Wang YP.   +8 more
europepmc   +1 more source