Results 331 to 340 of about 407,038 (348)

Accessible, realistic genome simulation with selection using stdpopsim

Gower G, Pope NS, Rodrigues MF, Tittes S, Tran LN, Alam O, Cavassim MIA, Fields PD, Haller BC, Huang X, Jeffrey B, Korfmann K, Kyriazis CC, Min J, Rebollo I, Rehmann CT, Small ST, Smith CCR, Tsambos G, Wong Y, Zhang Y, Huber CD, Gorjanc G, Ragsdale AP, Gronau I, Gutenkunst RN, Kelleher J, Lohmueller KE, Schrider DR, Ralph PL, Kern AD.   +30 more
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Exons – Introns = Lexons: In‐frame concatenation of exons by PCR

Human Mutation, 1998
A method for concatenating exons from genomic DNA, thereby skipping large stretches of intron sequence, has been developed using the polymerase chain reaction (PCR) with primers based on known intron-exon junction sequences. The use of genomic DNA circumvents the need for cDNA preparation for many purposes, including cDNA construction and mutational ...
Joanna Groden, Thérèse M. F. Tuohy
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Influence of Exon Duplication on Intron and Exon Phase Distribution

Journal of Molecular Evolution, 1998
Nonrandomness in the intron and exon phase distributions in a sample of 305 human genes has been found and analyzed. It was shown that exon duplications had a significant effect on the exon phase nonrandomness. All of the nonrandomness is probably due to both the processes of exon duplication and shuffling.
Eugeni Grigor'ev, Vadim Filatov, Alexey Yu. Fedorov, Valery Starshenko, Larisa Fedorova   +4 more
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Exons as enhancers

Nature Reviews Genetics, 2019
A study in Cell identifies a mechanism by which exon splicing can increase gene expression through the activation of weak upstream promoters.
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Isolation of Exons from Cloned DNA by Exon Trapping

Current Protocols in Human Genetics, 1994
AbstractExon trapping is an RNA polymerase chain reaction (PCR) method to clone expressed sequences or exons directly from mammalian genomic DNA. The basic protocol in this unit describes the method for trapping internal exons from cosmid clones and the second basic protocol describes trapping of 3 terminal exons.
Paul C. Watkins, Paul E. Nisson, David B. Krizman   +2 more
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The universe of exons revisited [PDF]

, 2003
We study the distribution of exons in eukaryotic genes to determine whether one can detect the reuse of exon sequences and to use the frequency of such reuse to estimate how many ancestral exon sequences there might have been. We use two databases of exons.
Serge Saxonov, Walter Gilbert
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Exons and the evolution of proteins

Trends in Biochemical Sciences, 1983
Publisher Summary This chapter discusses exons and evolution of proteins. The splitting of most eukaryotic structural genes into coding sequences (exons) and noncoding sequences (introns) is widely interpreted in terms of evolutionary processes concerned with the gene products.
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Exon–exon junction – what's your function?

Trends in Cell Biology, 2001
The expression of aberrant proteins can have disastrous consequences for a cell. Quality-control mechanisms that survey newly synthesized mRNAs are therefore essential to cellular well being. Unspliced pre-mRNAs are retained in the nucleus because they fail to associate with the appropriate export factors.
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