Results 121 to 130 of about 18,714 (239)

Genome-wide in silico screen for CCCH-type zinc finger proteins of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major. [PDF]

, 2010
BACKGROUND: CCCH type zinc finger proteins are RNA binding proteins with regulatory functions at all stages of mRNA metabolism. The best-characterized member, tritetraproline (TTP), binds to AU rich elements in 3' UTRs of unstable mRNAs, mediating their ...
Carrington, Mark, Kimblin, Nicola C, Kramer, Susanne   +2 more
core   +2 more sources

Ethylene

, 2017
Ethylene is a volatile 2-carbon atom molecule with hormonal properties in plants. In cross-talk with other hormones, it plays a pivotal role in controlling plant growth, through regulation of cell expansion.
Depaepe, Thomas, Van Der Straeten, Dominique   +1 more
core   +1 more source

Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [PDF]

, 2017
The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease.
Clark, Jordan J., Cumberworth, Stephanie, Donald, Claire L., Kohl, Alain   +3 more
core   +1 more source

Exoribonuclease-Resistant RNAs Exist within both Coding and Noncoding Subgenomic RNAs

mBio, 2018
Many viruses produce protein-coding and noncoding subgenomic RNAs (sgRNAs) that are critical for infection. A recently discovered pathway for viral sgRNA production uses exoribonuclease-resistant RNAs (xrRNAs), discrete folded RNA elements that block the
Anna-Lena Steckelberg, Quentin Vicens, Jeffrey S. Kieft   +2 more
doaj   +1 more source

Perlman syndrome nuclease DIS3L2 controls cytoplasmic non-coding RNAs and provides surveillance pathway for maturing snRNAs [PDF]

, 2016
The exosome-independent exoribonuclease DIS3L2 is mutated in Perlman syndrome. Here, we used extensive global transcriptomic and targeted biochemical analyses to identify novel DIS3L2 substrates in human cells.
Bijata, Krystian, Dziembowski, Andrzej, Krawczyk, Paweł, Kuliński, Tomasz M., Tomecki, Rafał, Warkocki, Zbigniew, Łabno, Anna   +6 more
core   +1 more source

Distinct 18S rRNA precursors are targets of the exosome complex, the exoribonuclease RRP6L2 and the terminal nucleotidyltransferase TRL in Arabidopsis thaliana [PDF]

, 2015
Pawel J. Sikorski, Hélène Zuber, Lucas Philippe, François M. Sement, Jean Canaday, Joanna Kufel, Dominique Gagliardi, Heike Lange   +7 more
openalex   +1 more source

Characterisation of the in-vivo miRNA landscape in Drosophila ribonuclease mutants reveals Pacman-mediated regulation of the highly conserved let-7 cluster during apoptotic processes

Frontiers in Genetics
The control of gene expression is a fundamental process essential for correct development and to maintain homeostasis. Many post-transcriptional mechanisms exist to maintain the correct levels of each RNA transcript within the cell.
Elisa I. M. Bernard, Benjamin P. Towler, Benjamin P. Towler, Oliver M. Rogoyski, Sarah F. Newbury   +4 more
doaj   +1 more source

Structural and biochemical characterization of eukaryotic mRNA decapping activators [PDF]

, 2014
In eukaryotes, mRNA turnover starts with the truncation of 3′ poly(A) tail and proceeds with either 3′-to-5′ degradation by the exosome complex or with decapping followed by 5′-to-3′ degradation by Xrn1.
Sharif, Humayun
core  

Crystal structures of CRISPR-associated Csx3 reveal a manganese-dependent deadenylation exoribonuclease [PDF]

, 2015
Xin‐Fu Yan, Wei Guo, Y. Adam Yuan
openalex   +2 more sources

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease [PDF]

, 2021
Berta Canal, Allison W. McClure, Joseph F. Curran, Mary Wu, Rachel Ulferts, Florian Weissmann, Jingkun Zeng, Agustina P. Bertolin, Jennifer C. Milligan, Souradeep Basu, Lucy S. Drury, Tom Deegan, Ryo Fujisawa, Emma L. Roberts, Clovis Basier, Karim Labib, Rupert Beale, Michael Howell, John F.X. Diffley   +18 more
openalex   +1 more source