Results 121 to 130 of about 14,025 (272)

A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection

Medicinal Research Reviews, Volume 45, Issue 2, Page 349-425, March 2025.
Abstract Infections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral ...
Seyedeh Zahra Bahojb Mahdavi, Asiyeh Jebelli, Parisa Shiri Aghbash, Behzad Baradaran, Mohammad Amini, Fatemeh Oroojalian, Nasser Pouladi, Hossein Bannazadeh Baghi, Miguel de la Guardia, Amir Ali Mokhtarzadeh   +9 more
wiley   +1 more source

Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5′-3′ exoribonuclease) in the nucleoplasm [PDF]

, 2015
Collaborator of alternative reading frame protein (CARF) associates directly with ARF, p53, and/or human double minute 2 protein (HDM2), a ubiquitin-protein ligase, without cofactors and regulates cell proliferation by forming a negative feedback loop ...
Bertwistle, Harunori Yoshikawa, Hasan, Hideaki Ishikawa, Keiichi Izumikawa, Nobuhiro Takahashi, Richard J. Simpson, Sauer, Shigeko Sato, Sugimoto, Yanagida, Yi, Zhang, Zhang   +13 more
core   +2 more sources

Genome-Wide Association Study for Maize Leaf Cuticular Conductance Identifies Candidate Genes Involved in the Regulation of Cuticle Development. [PDF]

, 2020
The cuticle, a hydrophobic layer of cutin and waxes synthesized by plant epidermal cells, is the major barrier to water loss when stomata are closed at night and under water-limited conditions.
Baseggio, Matheus, Chamness, James, Gore, Michael A, Kaczmar, Nicholas, Lin, Meng, Matschi, Susanne, Miller, Michael, Molina, Isabel, Qiao, Pengfei, Scanlon, Michael J, Smith, Laurie G, Stewart, Ethan L, Vasquez, Miguel   +12 more
core   +2 more sources

The crystal structure of a Polerovirus exoribonuclease-resistant RNA shows how diverse sequences are integrated into a conserved fold

bioRxiv, 2020
Exonuclease-resistant RNAs (xrRNAs) are discrete elements that block the progression of 5’ to 3’ exonucleases using specifically folded RNA structures.
Anna-Lena Steckelberg, Q. Vicens, D. Costantino, J. Nix, J. Kieft   +4 more
semanticscholar   +1 more source

Understanding GEMIN5 Interactions: From Structural and Functional Insights to Selective Translation

WIREs RNA, Volume 16, Issue 2, March/April 2025.
GEMIN5 structural domains. Overview of GEMIN5's role in snRNP assembly and translation regulatory events. ABSTRACT GEMIN5 is a predominantly cytoplasmic protein, initially identified as a member of the survival of motor neurons (SMN) complex. In addition, this abundant protein modulates diverse aspects of RNA‐dependent processes, executing its ...
Encarnacion Martinez‐Salas, Salvador Abellan, Rosario Francisco‐Velilla   +2 more
wiley   +1 more source

RNA Degradation Assay Using RNA Exosome Complexes, Affinity-purified from HEK-293 Cells

Bio-Protocol, 2017
The RNA exosome complex plays a central role in RNA processing and regulated turnover. Present both in cytoplasm and nucleus, the exosome functions through associations with ribonucleases and various adapter proteins (reviewed in [Kilchert et al., 2016]).
Michal Domanski, John LaCava
doaj   +1 more source

Evolutionarily conserved 5'-3' exoribonuclease Xrn1 accumulates at plasma membrane-associated eisosomes in post-diauxic yeast. [PDF]

PLoS ONE, 2015
Regulation of gene expression on the level of translation and mRNA turnover is widely conserved evolutionarily. We have found that the main mRNA decay enzyme, exoribonuclease Xrn1, accumulates at the plasma membrane-associated eisosomes after glucose ...
Tomas Grousl, Miroslava Opekarová, Vendula Stradalova, Jiri Hasek, Jan Malinsky   +4 more
doaj   +1 more source

Arabidopsis exoribonuclease USB1 interacts with the PPR-domain protein SOAR1 to negatively regulate abscisic acid signaling

Journal of Experimental Botany, 2020
USB1, an exoribonuclease catalyzing U6 production for spliceosome assembly, negatively regulates, cooperatively with SOAR1, ABA signaling in early seedling development, probably by affecting spliceosome assembly.
Yu Ma, Shang Zhang, Chao Bi, Chao Mei, Shang-Chuan Jiang, Xiao-fang Wang, Z. Lu, Da-Peng Zhang   +7 more
semanticscholar   +1 more source

Dysregulated ribosome quality control in human diseases

The FEBS Journal, Volume 292, Issue 5, Page 936-959, March 2025.
Ensuring the synthesis of full‐length, correctly folded proteins is vital for maintaining homeostasis. If a translating ribosome stalls, the trailing ribosomes collide into it, which if left unresolved leads to deleterious effects on the cell due to the accumulation of protein aggregates.
Tom McGirr, Okan Onar, Seyed Mehdi Jafarnejad   +2 more
wiley   +1 more source

Disruption of Zika Virus xrRNA1-Dependent sfRNA1 Production Results in Tissue-Specific Attenuated Viral Replication

Viruses, 2020
The Zika virus (ZIKV), like other flaviviruses, produces several species of sub-genomic RNAs (sfRNAs) during infection, corresponding to noncoding RNA fragments of different lengths that result from the exonuclease degradation of the viral 3 ...
Hadrian Sparks, Brendan Monogue, Benjamin Akiyama, Jeffrey Kieft, J. David Beckham   +4 more
doaj   +1 more source