Results 211 to 220 of about 143,013 (333)

Exosomes derived from avian influenza virus-infected chickens modulate host immune responses. [PDF]

Poult Sci
Kim C, Phan TH, Truong AD, Hong YH.
europepmc   +1 more source

Senescent Synovial Intimal Fibroblasts Aggravate Osteoarthritis by Regulating Macrophage Polarization and Chondrocyte Phenotype Through ANGPTL4‐α5β1 Axis

Advanced Science, EarlyView.
Senescent synovial intimal fibroblasts (SIF) are identified as key drivers of osteoarthritis. They promote M1 macrophage polarization and cartilage degeneration via the ANGPTL4–α5β1 axis, regulated by transcription factors EGR1 and ATF3. Pharmacological inhibition of this pathway alleviates disease, revealing SIF senescence as a promising therapeutic ...
Muhai Deng, Yunsheng Jiang, Zhiyu Chen, Kaiquan Chen, Na Cao, Yang Huang, Zhengxue Quan, Cheng Chen   +7 more
wiley   +1 more source

Hybrid exosomes: a rising horizon for precision cancer therapy. [PDF]

RSC Adv
Sonar S, Das A, Nyahatkar S, Dhar R, Kalele K, Balasubramaniam VRMT, Wong LS, Kumarasamy V, Subramaniyan V.   +8 more
europepmc   +1 more source

Machine Learning‐Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface‐Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring

Advanced Science, EarlyView.
Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong, Jiaqi Wang, Sijun Huang, Xiaxia Man, Yi Guo, Shuping Xu, Songling Zhang   +6 more
wiley   +1 more source

Systematic Mining of Bioactive Compounds for Wound Healing From <i>Cayratia Japonica</i> Exosome-Like Nanovesicles: A Workflow Combining LC-MS and DeepSeek Models. [PDF]

JMIR Bioinform Biotechnol
Fu Q, Ji W, Fan YP, Yao J, Song MX, Yan QJ.   +5 more
europepmc   +1 more source

Engineered Small Extracellular Vesicles Targeting Tumor‐Associated Endothelial Cells to Effectively Remodel the Glioma Microenvironment

Advanced Science, EarlyView.
This study developed a novel drug delivery platform that overcomes the blood‐brain barrier in glioblastoma. By fusing IGFBP7 with small extracellular vesicles, the platform specifically targets tumor vasculature. It effectively delivers temozolomide, suppressing tumor growth at low doses.
Lingling Liu, Feiyang Xu, Zhiming Zheng, Xiaodan Yang, Fang Yang, Pei Liu, Yuankun Chen, Yunshu Yang, Junli Zhao, Peiyan Yang, Xiaojing Zheng, Xiaohong Sun, Ping Mao, Qinwen Mao, Hao Guan, Haibin Xia, Weifeng Zhang, Dan Xiao   +17 more
wiley   +1 more source

Inhalation & intravenous: umbilical cord mesenchymal stem cell-derived exosomes therapy strategy for acute respiratory distress syndrome in a murine model. [PDF]

J Thorac Dis
Yang L, Cao Z, Xing Y, Pan Y, Yang C, Zhang L, Zhao H, Ma T, Ye H.   +8 more
europepmc   +1 more source

Role of exosomes in exacerbations of asthma and COPD: a systematic review [PDF]

Rossella Laitano, Luigino Calzetta, Enrico Motta, Ermanno Puxeddu, Paola Rogliani   +4 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Therapeutic Exosomes Carrying <i>VEGFA</i> siRNA Inhibit Pathological Corneal Angiogenesis via PI3K-Akt-Caspase-3 Signaling. [PDF]

Biomedicines
Hur W, Bhujel B, Lee S, Oh S, Chung HS, Lee H, Kim JY.   +6 more
europepmc   +1 more source