Results 251 to 260 of about 182,132 (342)

Anti‐Swelling Hydrogel Combined With Nucleus Pulposus Cell Exosomes and Senolytic Drugs Efficiently Repair Intervertebral Disc Degeneration

Advanced Science, EarlyView.
In this study, a bifunctional anti‐swelling hydrogel system is developed, which encapsulated anti‐senescence drugs quercetin, dasatinib, nucleus pulposus‐derived exosomes (NP‐Exo) to clear senescent nucleus pulposus cells, regulate the inflammatory disc microenvironment, and enhance nucleus pulposus cells activity, ultimately promoting the repair of ...
Songfeng Chen, Hao Han, Yuhao Zhang, Longyu Li, Zhishuo Wang, Jiaming Zhang, Liang Han, Hongwei Kou, Guowei Shang, Chunfeng Shang, Zikuan Leng, Keya Mao, Chengwei Li, Lin Jin, Hongjian Liu   +14 more
wiley   +1 more source

Identification of exosome-related gene biomarkers for parkinson's disease: a multi-omics approach for early diagnosis and therapeutic targeting. [PDF]

BMC Neurol
Chen S, Feng N, Liu Y.
europepmc   +1 more source

Crosstalk between the tumor microenvironment and tumor cells through exosomes: Roles in tumor metabolism and progression

, 2023
Yinghui Shi, Jian Du, Wen Pan, Haiyang Zhang, Yi Ba   +4 more
openalex   +1 more source

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

Nature Neuroscience, 2015
Hirohide Asai, Seiko Ikezu, S. Tsunoda, Maria Medalla, J. Luebke, T. Haydar, B. Wolozin, O. Butovsky, S. Kügler, T. Ikezu   +9 more
semanticscholar   +1 more source

Bone Marrow Mesenchymal Stem Cell Hydrogel‐Mediated Fibroblast Reprogramming Restores Intestinal Function in Adhesive Small Bowel Obstruction

Advanced Science, EarlyView.
Conceptual diagram and schematic illustration of microenvironmental changes in individuals with ASBO before and after treatment. BMSC@Gel therapy transforms the ASBO microenvironment from an inflammatory, fibrotic state with aberrant matrix deposition and barrier dysfunction to a regenerative state with reduced inflammation and improved structural ...
Lihong Zheng *, Junrong Zhang *, Zhengyuan Huang *, Zhenliang Lin, Jin Zhang, Da Zhang, Ping Hou, Xianqiang Chen   +7 more
wiley   +1 more source

Identification of an anti-inflammatory action of exosome release in P2Y₄ loss-mediated cardioprotection. [PDF]

Front Pharmacol
Diaz Villamil E, Rouvier P, Horckmans M, De Roeck L, Hendrickx E, Conrard L, Communi D.   +6 more
europepmc   +1 more source

Immunometabolic Rewiring of Dendritic Cells to Overcome Glutamine‐Driven Immune Suppression in Colorectal Cancer

Advanced Science, EarlyView.
T26 is an immunometabolic prodrug that modulates colorectal cancer cells. It blocks glutamine metabolism and enhances STING signaling, which promotes the release of reprogrammed extracellular vesicles. These vesicles drive dendritic cell maturation and CD8⁺ T cell activation, thereby strengthening antitumor immunity and improving the effectiveness of ...
Bingjie Zhang, Renming Fan, Yongrui Hai, Ye Chen, Xintong Lu, Wenhui Wang, Jiarui Dou, Jiaxin Yan, Chang Su, Yue Chen, Le Yang, Minggao Zhao, Lei Liang, Gaofei Wei   +13 more
wiley   +1 more source

Recombinant Hydrophobic Polypeptide MBAY Loaded Into SPION-Exosome Realizes Sustained-Release to Improve Type 2 Diabetes Mellitus

Drug Design, Development and Therapy
Xinyu Zong,1,2,* Shangying Xiao,3,* Haishan Xia,3 Dan Guo,1 Jiaping Wu,1 Manjiao Zhuang,3 Lei Rao1 1Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Medical College, Shaoguan ...
Zong X, Xiao S, Xia H, Guo D, Wu J, Zhuang M, Rao L   +6 more
doaj  

Adverse Reactions Following Intradermal Injection of Exosome-Based Formulations: A Case Series. [PDF]

J Cosmet Dermatol
Park KY.
europepmc   +1 more source

Healthy Tendon Stem Cell‐Derived Exosomes Promote Tendon‐To‐Bone Healing of Aged Chronic Rotator Cuff Tears by Breaking the Positive‐Feedback Cross‐Talk between Senescent Tendon Stem Cells and Macrophages through the Modulation of Macrophage Polarization [PDF]

Xuancheng Zhang, Wei Song, Yang Liu, Kang Han, Yuxu Wu, Eunshinae Cho, Zhaoyi Fang, Lianghua Jiang, Yihe Hu, Xuesong Zhu, Jia Jiang, Xiaoqiao Huangfu, Jinzhong Zhao   +12 more
openalex   +1 more source