Results 251 to 260 of about 130,935 (361)

Alzheimer's disease β-amyloid peptides are released in association with exosomes [PDF]

, 2006
Lawrence Rajendran, Masanori Honsho, Tobias Zahn, Patrick Keller, Kathrin Geiger, Paul Verkade, Kai Simons   +6 more
openalex   +1 more source

In Situ Programming of the Tumor Microenvironment to Alleviate Immunosuppression for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
cmExoaCD11b induced the repolarization of immunosuppressive M2 macrophages into pro‐inflammatory M1 phenotype, thereby promoting the proliferation and activation of CD8+ T cells and reversing the immunosuppressive state of the tumor microenvironment.
Man Sun, Huan Zhang, Yarui Ma, Simiao Wang, Jiayi Chen, Yaxin Cui, Yun Zhang, Siyuan Hu, Dan Zhou, Pengchen Zhang, Yahui Liu, Betty Y.S. Kim, Wen Jiang, Xiaobing Wang, Zhaogang Yang   +14 more
wiley   +1 more source

MiRNA-29b accelerates the PDGF in exosomes and stimulates hepatic stellate cells to promote liver fibrosis in biliary atresia. [PDF]

Eur J Med Res
Liao X, Liu R, Zhou T, Zhao X, Xiong X, Zhang K, Zheng Z, Xia X, Tang C, Gong Y, Du Q, Huang L, Zhu D, Zhou W, Liu Y, Jin Z.   +15 more
europepmc   +1 more source

Pancreatic Cancer‐Derived Extracellular Vesicles Enriched with miR‐223‐5p Promote Skeletal Muscle Wasting Associated with Cachexia

Advanced Science, EarlyView.
EVs and EV‐microRNAs (miRNAs) mediate PDAC‐skeletal muscle communication. miR‐223‐5p reduces METTL14 transcription by targeting MAFA, which subsequently decreases m6A methylation in skeletal muscles, ultimately leading to muscle wasting. This study highlights the absorption of miRNA in PDAC‐derived EVs by skeletal muscles and reveals a previously ...
Kangjing Xu, Rongxi Shen, Li Zhang, Xuejin Gao, Xinbo Wang, Changhua Zhang, Xi Chen, Xinying Wang   +7 more
wiley   +1 more source

Targeting Exosomal PD-L1 as a New Frontier in Cancer Immunotherapy. [PDF]

Curr Issues Mol Biol
Dragu LD, Chivu-Economescu M, Pitica IM, Matei L, Bleotu C, Diaconu CC, Necula LG.   +6 more
europepmc   +1 more source

Neutrophil‐Mimicking Nanomedicine Eliminates Tumor Intracellular Bacteria and Enhances Chemotherapy on Liver Metastasis of Colorectal Cancer

Advanced Science, EarlyView.
Fusobacterium nucleatum (Fn) enrichment has been identified in colorectal cancer and its liver metastases. This study develops neutrophil‐mimicking nanoparticles with multiple targeting capabilities encapsulating metronidazole and oxaliplatin for antibacterial and anticancer purposes. This approach reverses the epithelial mesenchymal transition process
Yanan Niu, Xu Zhao, Yong Li, Xiaoya Ma, Weifeng Yang, Jie Ma, Wanglin Li, Wei Yuan   +7 more
wiley   +1 more source

Exosomal PD-L1 detection in cancer predictive biomarker for response to immune checkpoint blockade therapy. [PDF]

Front Immunol
Kansha T, Ma X, Wang H, Yu X, Song Y, Guo Z, Song J, Xue L, Yang J.   +8 more
europepmc   +1 more source

A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44 [PDF]

, 2006
Alexander Stoeck, Sascha Keller, Svenja Riedle, Michael P. Sanderson, Steffen Runz, François Le Naour, Paul Gutwein, Andreas Ludwig, Eric Rubinstein, Peter Altevogt   +9 more
openalex   +1 more source

Autophagy‐Mediated Suppression of Tumor Growth by Food‐Grade Lipid Nanoparticles in Mice

Advanced Science, EarlyView.
This work reveals a novel extracellular nanoparticle transport and metabolic pathway. Following cellular uptake, Food‐grade lipid nanoparticles (FLNs) selectively fuse with lipid droplets (LDs) rather than lysosomes, driving LDs accumulation. This process activates autophagy through the AMPK‐mTOR‐ULK1 signaling axis, facilitating tumor progression ...
Chenglu Peng, Bing Jiang, Wei Lu, Przemyslaw Zalewski, Jun He, Xiaoyang Li, Yiping Cao, Yiguo Zhao, Cuixia Sun, Katsuyoshi Nishinari, Yapeng Fang   +10 more
wiley   +1 more source

Exosomes in hypoxia: generation, secretion, and physiological roles in cancer progression. [PDF]

Front Immunol
Mu Y, Yang M, Liu J, Yao Y, Sun H, Zhuang J.   +5 more
europepmc   +1 more source