Cancer Communications, EarlyView.Abstract Background Glioblastoma (GBM) is largely refractory to antibodies against programmed cell death 1 (anti‐PD‐1) therapy. Fully understanding the cellular heterogeneity and immune adaptations in response to anti‐PD‐1 therapy is necessary to design more effective immunotherapies for GBM.
Rongrong Zhao +11 more
wiley +1 more source
Molecular Mechanism of Processive 3' to 5' RNA Translocation in the Active Subunit of the RNA Exosome Complex. [PDF]
J Am Chem Soc, 2016 Vuković L +4 more
europepmc +1 more source
The fission yeast MTREC complex targets CUTs and unspliced pre-mRNAs to the nuclear exosome [PDF]
, 2015 Yang Zhou +7 more
openalex +1 more source
Combating cancer immunotherapy resistance: a nano‐medicine perspective
Cancer Communications, EarlyView.Abstract Cancer immunotherapy offers renewed hope for treating this disease. However, cancer cells possess inherent mechanisms that enable them to circumvent each stage of the immune cycle, thereby evading anti‐cancer immunity and leading to resistance.
Xiangyi Kong +10 more
wiley +1 more source
Advances in Cytosolic Delivery of Proteins: Approaches, Challenges, and Emerging Technologies
Chemistry &Biodiversity, EarlyView.Proteins regulate almost all biological processes, and overcoming the protein's natural membrane inpermeability will provide a unique opportunity for intracellular targeting of related therapeutic proteins. Chemical modification of proteins and different types of delivery vectors can mediate intracellular transport of proteins, providing new ideas for ...
Wenyan Zhang +8 more
wiley +1 more source
RNA Exosome Complex Regulates Stability of the Hepatitis B Virus X-mRNA Transcript in a Non-stop-mediated (NSD) RNA Quality Control Mechanism [PDF]
, 2016 Hussein H. Aly +7 more
openalex +1 more source
The yeast exosome and human PM-Scl are related complexes of 3' right-arrow 5' exonucleases
, 1999 Christine Allmang +5 more
openalex +1 more source
Cutting‐Edge Aptasensing Approaches for Electrochemical Detection of Exosomes Utilizing MXenes
ChemElectroChem, EarlyView.This work notably summarizes research on 2D MXenes/MXene's‐hybrid‐based nanoplatforms patterned with aptamers as an alternative to antibodies affording highly sensitive and robust biosensing of exosomes as well as their efficient isolation. The exosomes are highlighted as a valuable source of biomarkers and with the immobilization approaches of ...
Andrej Vikartovský +5 more
wiley +1 more source
ChemMedChem, EarlyView.Molecular metal‐bis(dithiolene) photothermal agents are efficiently incorporated into water‐dispersible nanoparticles (NPs) constituted by a biocompatible polymer derived from poly(malic acid). The photoacoustic activity of these NPs is evaluated, and their photothermal properties under near‐infrared irradiation are used for photothermal therapy of ...
Jean‐Baptiste Pluta +10 more
wiley +1 more source
DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs. [PDF]
Mol Cell, 2015 Macias S +4 more
europepmc +1 more source