Results 271 to 280 of about 202,629 (353)

Recent advances in animal models for pathological scar research: A comprehensive review of experimental approaches and translational relevance

Animal Models and Experimental Medicine, EarlyView.
Animal models remain indispensable in the study of pathological scars, each offering unique advantages and constraints. Their integration with in vitro and ex vivo systems is key to developing personalized, clinically translatable antifibrotic therapies. Abstract Pathological scarring, manifested in the form of hypertrophic scars (HTS) and keloid scars
Diana‐Larisa Ancuța, Mariana Văduva, Cristin Coman, Iuliana Caraș   +3 more
wiley   +1 more source

Back Again to the Future: A New Era for Cerebroprotection

Annals of Neurology, EarlyView.
Cerebroprotection is a fresh framework for designing neurological therapy that targets glia and vascular cells, in addition to neurons. In the future, successful cerebroprotection will involve targeting all elements of the neurovascular unit. Preclinical trials must include functional outcomes, as well as lesion morphometry.
Patrick Lyden
wiley   +1 more source

Engineering exosomes for cancer therapy - Modification technologies and subcellular targeting strategies: A review. [PDF]

Int J Pharm X
Liu F, Xia C, Yu H, Yang X, Ge L, Ye C.
europepmc   +1 more source

SERS-NanozymeCooperative Ag@Lacunary-POM Nanoclustersfor Exosome Biosensing

Qingnan Zhao (6850277), Saizhen Hu (15357953), Fan Wang (135182), Feng Lin (23861), Bing Zhao (29538), Wei Song (30780)   +5 more
openalex   +1 more source

Redox‐Responsive Mitochondrial Delivery from Functionalized Vascular Stent Surfaces

Advanced NanoBiomed Research, EarlyView.
A redox‐responsive stent surface is engineered to deliver functional mitochondria in response to oxidative stress. Upon exposure to reactive oxygen species, grafted mitochondria are released, internalized by vascular cells, and restore mitochondrial function under stress.
Fang Tang, Brandon C. Applewhite, Bowen Wang, Bin Jiang   +3 more
wiley   +1 more source

Mesenchymal Stem Cell-Derived Exosomes: A Promising Therapeutic Strategy for Spinal Cord Injury. [PDF]

Int J Nanomedicine
Li X, Wang C, Du K, Wang J, Lin J, Yang C.   +5 more
europepmc   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Combined action of suicide gene exosomes from pancreatic cancer-associated fibroblasts and from mesenchymal stem cells as a pancreatic ductal adenocarcinoma treatment approach. [PDF]

Cancer Cell Int
Jakubechova J, Altanerova U, Andrezal M, Vanova D, Zeleznikova T, Bartek P, Cihova M, Smolkova B, Buocikova V, Makovicky P, Jakic K, Burikova M, Urbanova M, Repaska V, Spanik B, Tomas M, Dubovan P, Kolnikova G, Zdrahal Z, Pustka V, Potesil D, Altaner C.   +21 more
europepmc   +1 more source

Chicken Pulmonary MicroRNAs Targeting the PB2 (Segment 1) of Avian Influenza Virus

Animal Research and One Health, EarlyView.
The PB2 segment of H5N1 is essential for replication and host adaptation. We screened 200 miRNAs and identified five (gga‐miR‐17‐3p, gga‐miR‐29a‐5p, gga‐miR‐1718, gga‐miR‐16c‐5p, and gga‐miR‐1744‐5p) using thermodynamic stability of heteroduplex, seed sequence complementarity, conservation, and accessibility, offering insights into host antiviral ...
Akanksha Choudhary, Nidhishree N. S, Rakesh Kumar Pundir, Muhasin Asaf V. N, Anamika Mishra, Ashwin Ashok Raut, Megha Agarwal, Amod Kumar   +7 more
wiley   +1 more source

Exosomes: A Comprehensive Exploration of their Beneficial, Detrimental, and Ambiguous Roles in Intercellular Communication and Pathophysiological Processes - Do They Justify the Enthusiasm?

Indian J Dermatol
Kapoor R, Bellani D, Patil R, Gold M, Shome D.   +4 more
europepmc   +1 more source