Results 91 to 100 of about 504,210 (296)

Meeting the rare earth expanding circle

Access Microbiology, 2019
The increasing demand for rare earth elements (REE) is fuelled by their importance in a green energy future, with the demand for dysprosium predicted to increase by 5 % annually by 2026. Bioleaching approaches are being investigated for the recovery of REE and other precious metals from waste materials, however even 100 % recovery will not be able to ...
Megan Barnett, Simon Gregory, Eimear Deady, Barbara Palumbo-Roe   +3 more
openaire   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Rhoticity in Chinese English: An experimental investigation on the realization of the variant (r) in an Expanding Circle variety

Revista Alicantina de Estudios Ingleses, 2017
The realization of postvocalic /r/ has been frequently examined in both diachronic and synchronic research on world Englishes, showing a multitude of linguistic and extra-linguistic factors to modulate the degree of rhoticity.
Li, Zeyu, Kabak, Barış
doaj   +1 more source

Ergodic theory of generic continuous maps

, 2012
We study the ergodic properties of generic continuous dynamical systems on compact manifolds. As a main result we prove that generic homeomorphisms have convergent Birkhoff averages under continuous observables at Lebesgue almost every point. In spite of
Abdenur, Flávio, Andersson, Martin
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

On the parametric dependences of a class of non-linear singular maps

, 2003
We discuss a two-parameter family of maps that generalize piecewise linear, expanding maps of the circle. One parameter measures the effect of a non-linearity which bends the branches of the linear map.
Dorfman, J. R., Gilbert, T.
core   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Virtual social media communities and their effects on World Englishes

Journal of Language and Cultural Education
This paper investigates the impact of social media use and virtual communities on world Englishes. The term world Englishes refers to the different varieties of how English is communicated worldwide. Kachru (1985) described the language’s spread in terms
Almohawes Monera
doaj   +1 more source

Convergent Calculation of the Asymptotic Dimension of Diffusion Limited Aggregates: Scaling and Renormalization of Small Clusters

, 2000
Diffusion Limited Aggregation (DLA) is a model of fractal growth that had attained a paradigmatic status due to its simplicity and its underlying role for a variety of pattern forming processes.
Anders Levermann, B. Davidovitch, B. Davidovitch, B. Davidovitch, B.B. Mandelbrot, Benny Davidovitch, H.G.E. Hentschel, Itamar Procaccia, J. Nittman, L. Niemeyer, M.B. Hastings, P. Meakin, P.L. Duren, R.M. Brady, T.A. Witten, T.C. Halsey, T.C. Halsey   +16 more
core   +1 more source