Results 71 to 80 of about 46,064 (302)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Expanding endomorphisms of the circle revisited [PDF]
Ergodic Theory and Dynamical Systems, 1985 AbstractTwo Cr, r ≥ 2, expanding maps of the circle which are absolutely continuously conjugate are Cr conjugate. Here ƒ and g: S1 → S1 are expanding if they stretch tangent vectors in some metric, and a conjugacy is an isomorphism h: S1 → S1 such that fh = hg.
Shub, Michael, Sullivan, Dennis
openaire +2 more sources
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Corpus-based Study of Institutional Academic ELF in the Expanding Circle
, 2012 This paper reports on an ongoing project focusing on institutional (vs. disciplinary) academic English as a Lingua Franca as it is used on the websites of European universities.
VENUTI, MARCO +4 more
core
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Lyapunov optimizing measures for C-1 expanding maps of the circle
, 2008 For a generic C-1 expanding map of the circle, the Lyapunov maximizing measure is unique and fully supported, and has zero ...
Morris, Ian D., Jenkinson, Oliver
core +1 more source
Beyond The Surface of Language Learning. An Analysis of EFL Textbooks and Their Representation of Inner, Outer, and Expanding Circle Cultures [PDF]
, 2022 The aim of this study was to analyze EFL textbooks used in Swedish upper secondary schools to investigate the representation of Kachru’s three Circles of English – the Inner, Outer, and Expanding Circle – as well as their cultures.
Lejonord, Juliette
core
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source