Results 51 to 60 of about 43,491 (264)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Circle diffeomorphisms forced by expanding circle maps [PDF]

Ergodic Theory and Dynamical Systems, 2011
AbstractWe discuss the dynamics of skew product maps defined by circle diffeomorphisms forced by expanding circle maps. We construct an open class of such systems that are robustly topologically mixing and for which almost all points in the same fiber converge under iteration. This property follows from the construction of an invariant attracting graph
openaire   +5 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Proceedings from the Third International Post-Tuberculosis Symposium: expanding the circle

IJTLD Open
SUMMARY: In light of the recent growth in interest and knowledge of post-TB sequelae, there were high levels of engagement during the 3rd International Post-Tuberculosis Symposium held in Stellenbosch, South Africa.
B.W. Allwood, S.C. Auld, B. Beko, G.P. Bisson, C.P. Borges de Almeida, A. Byrne, F.C. Chow, A. Davis, S. Defres, M. Drage, D. Evans, X. Gai, G. Günther, A.N. Gupte, G. Hoddinott, M.A. Huaman, S. Huddart, J. Huynh, G. Kalyatanda, C. Khosa, T. Kutadza, G. Makanda, S. Marais, J. Meghji, N. Navuluri, E. Nkereuwem, A. Rajaratnam, K. Romanowski, I. Schoeman, J.A. Seddon, H. Sohn, F. Thienemann, D.T. Wademan, N.F. Walker, M.M. van der Zalm, R. Nightingale   +35 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

English as a Lingua Franca: A New Variety in the New Expanding Circle?

NJES: Nordic Journal of English studies, 2006
The traditional tripartite model of English world-wide has so far ignored one of the most important functions of English today, namely that of a lingua franca between non-native speakers.
Sandra Mollin
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Evaluation in Australasia: An Overview of Recent Developments

Journal of MultiDisciplinary Evaluation, 2007
Evaluation activities continue to develop throughout Australasia as evidenced by the Australasia Evaluation Society (AES) expanding its circle of influence and reaching out to its neighbors in Vietnam and China.
Wes Martz
doaj   +1 more source

Expanding endomorphisms of the circle revisited [PDF]

Ergodic Theory and Dynamical Systems, 1985
AbstractTwo Cr, r ≥ 2, expanding maps of the circle which are absolutely continuously conjugate are Cr conjugate. Here ƒ and g: S1 → S1 are expanding if they stretch tangent vectors in some metric, and a conjugacy is an isomorphism h: S1 → S1 such that fh = hg.
Shub, Michael, Sullivan, Dennis
openaire   +2 more sources

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source