Results 51 to 60 of about 45,827 (266)

Completing the Circle

African Christian Theology
The Circle of Concerned African Women Theologians is celebrating thirty-five years of communal theology through research and writing and through intentional mentorship to increase the number of women in the pulpits and in academia.
Esther MOMBO, Jackline MAKENA
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circle diffeomorphisms forced by expanding circle maps [PDF]

Ergodic Theory and Dynamical Systems, 2011
AbstractWe discuss the dynamics of skew product maps defined by circle diffeomorphisms forced by expanding circle maps. We construct an open class of such systems that are robustly topologically mixing and for which almost all points in the same fiber converge under iteration. This property follows from the construction of an invariant attracting graph
openaire   +5 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Proceedings from the Third International Post-Tuberculosis Symposium: expanding the circle

IJTLD Open
SUMMARY: In light of the recent growth in interest and knowledge of post-TB sequelae, there were high levels of engagement during the 3rd International Post-Tuberculosis Symposium held in Stellenbosch, South Africa.
B.W. Allwood, S.C. Auld, B. Beko, G.P. Bisson, C.P. Borges de Almeida, A. Byrne, F.C. Chow, A. Davis, S. Defres, M. Drage, D. Evans, X. Gai, G. Günther, A.N. Gupte, G. Hoddinott, M.A. Huaman, S. Huddart, J. Huynh, G. Kalyatanda, C. Khosa, T. Kutadza, G. Makanda, S. Marais, J. Meghji, N. Navuluri, E. Nkereuwem, A. Rajaratnam, K. Romanowski, I. Schoeman, J.A. Seddon, H. Sohn, F. Thienemann, D.T. Wademan, N.F. Walker, M.M. van der Zalm, R. Nightingale   +35 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

English as a Lingua Franca: A New Variety in the New Expanding Circle?

NJES: Nordic Journal of English studies, 2006
The traditional tripartite model of English world-wide has so far ignored one of the most important functions of English today, namely that of a lingua franca between non-native speakers.
Sandra Mollin
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Expanding endomorphisms of the circle revisited [PDF]

Ergodic Theory and Dynamical Systems, 1985
AbstractTwo Cr, r ≥ 2, expanding maps of the circle which are absolutely continuously conjugate are Cr conjugate. Here ƒ and g: S1 → S1 are expanding if they stretch tangent vectors in some metric, and a conjugacy is an isomorphism h: S1 → S1 such that fh = hg.
Shub, Michael, Sullivan, Dennis
openaire   +2 more sources